OB 1.1 Flashcards
Persistent vomiting aggravated by inability to take in food leading to severe dehydration and ketonuria
Hyperemesis gravidarum
Disturbances in urination is most prominent during
2nd and 3rd months
Easy fatigability in normal pregnancy is due to
Increased BMR
First perception by mother of fetal movement
Quickening
Quickening: Primigravida
18-20 weeks
Quickening: Multigravida
16-18 weeks
T/F Quickening increases in intensity and frequency as pregnancy progresses
T
Hormone: Stimulate mammary DUCT system
Estrogen
Hormone: Stimulate ALVEOLAR components of breast
Progesterone
Earliest sign of pregnancy
Cessation of menstruation
Highly suspect pregnancy if ___ days have elapsed after expected onset of menses
10 or more
Expression of colostrum is appreciated at ___ week
16th
T/F There is no relation between pre-pregnant breast size and volume of milk production during lactation
T
Hormone: Thermal changes in pregnancy
Progesterone
Luteal vs follicular phase: Greater basal body temp
Luteal
Temp in luteal phase is ___ degrees higher than in follicular phase
0.3-0.5C
Hormone: Skin pigmentation changes
Estrogen and progesterone
T/F Skin pigmentation is more prominent in dark-skinned individuals
T
T/F Skin pigmentation in pregnancy is intensified by exposure to sunlight
T
Reddish, slightly depressed streaks commonly found in abdominal skin that may turn silvery white after delivery
Striae gravidarum
Striae gravidarum is due to
Separation of underlying collagen tissue
Hormone: Decreased peripheral vascular resistance
Estrogen
More rapid growth as uterus rises out of pelvis: Weeks
16-22 weeks
Time during which fundic height is equal to gestational age, i.e. x cm = x weeks AOG
16-32 weeks
T/F Abdominal enlargement is more pronounced in
multigravida than primigravida
T
T/F Uterine growth is limited to anteroposterior
diameter
T
Average diameter of uterus at 12 weeks AOG
8 cm
Hegar sign is appreciated at ___ weeks
6-8
T/F At about 4 weeks AOG external cervical os and cervical canal become patulous (open/distended) to allow insertion of fingertip
T
Hormone: Ferning of cervical mucus
Estrogen
In non-pregnant women, ferning of cervical mucus is appreciated at days ___ of cycle
7-18
In non-pregnant women, beading of cervical mucus is appreciated at day ___ of cycle
21
Predominant hormone in pregnancy
Progesterone
False labor pain
Braxton-Hicks contraction
Intensity of Braxton-Hicks contractions
5-25 mmHg
When are Braxton Hicks contractions felt most
28 weeks AOG
HCG in pregnancy is produced by
Fetal trophoblasts
Function of HCG in pregnancy
Maintains the corpus luteum which is the main site of progesterone production in early pregnancy
HCG: Doubling time
1.4-2 days
α subunit of HCG is similar to that of (3)
1) LH
2) FSH
3) TSH
False positive sandwich type immunoassay pregnancy test is due to
Heterophile antibodies
Detection limit of home pregnancy tests
12.5 mIU/mL
Normal FHT
110-160 bpm
Most accurate method of determining FHT
UTZ
Soft, blowing sound synchronous with maternal pulse
Uterine souffle
Sharp, whistling sound that is synchronous with fetal pulse
Funic souffle or umbilical cord souffle
Uterine souffle: Passage of blood through
Uterine vessels
Funic souffle or umbilical cord souffle: Passage of blood through
Umbilical arteries
Fetal movement can be perceived by the examiner at what week
20th
Week: Gestational sac
5
Week: Fetus w/in gestational sac & fetal heart beat detected
6
Week: CRL measurement is predictive of
gestational age
6-12
Imaginary or spurious pregnancy
Pseudocyesis
Pseudocyesis is usually seen in what population
Women nearing menopause or with strong desire to become pregnant
Most convincing method for women who have pesudocyesis
Ultrasound
T/F Pregnancy test kits are reliable means of identifying fetal death
F, trophoblasts continue to produce hcg for several days or weeks after fetal demise
Nonviability of a pregnancy is best confirmed by
Ultrasound
Usually the most noticeable symptom in fetal demise
Cessation of fetal movement
Overlapping of the fetal skull bones due to liquefaction of the brain
Spalding sign
Gas bubbles in the fetus
Robert sign
Phases of parturition
1) Quiescence
2) Preparation for labor
3) Process of stimulation or labor
4) Parturient recovery
Hormone: Dominant in phase 0 of parturition
Progesterone
Gap junction for interaction between uterine smooth muscle cells that is inhibited by progesterone
Connexin 43
Hormone: Promotes formation of connexin 43
Estrogen
Promoters of myometrial relaxation (7)
1) Beta adrenoreceptors
2) LH and HCG
3) Relaxin
4) CRH
5) PTH-rp
6) PGD2, E2, I2
7) ANP and BNP
Hormone: Cevical ripening
Relaxin
Hormone: Can induce both uterine relaxation and contraction
CRH
Phase 2 of parturition commences at
37 weeks AOG
Phase of parturition: Development of uterine sensitivity
Phase 2
Phase of parturition: T/F Phase 2 is the phase where most uterotonins are active
T
Phase of parturition: Progesterone withdrawal
Phase 2
Hormone: Upregulation of oxytocin receptors
Estrogen
Sensation that a pregnant woman feels that the baby has descended
Lightening
Important events at 37 weeks AOG (3)
1) Formation of LUS
2) Cervical softening
3) Lightening
Cervical softening in phase 2 of parturition is due to
Breakdown of collagen fibers
Placental source of CRH
Cytotrophoblast
Hormone: Goes to pituitary of fetus stimulating release of steroids that will act on lungs to promote pulmonary maturity
CRH
Major substrate for estrogen production
C19 steroids
Production of CRH from placenta stops when
After release of fetus
Hormone: Stimulates membranes to increase prostaglandin
synthesis, which is a potent uterotonin
CRH
Hormone: Stimulate fetal adrenals to produce C19 steroids
leading to increased substrate for placental aromatization
CRH
Fetal anomalies that may cause delayed parturition
1) Hypoestrogenism
2) Anencephaly
3) Adrenal hypoplasia
4) Placental sulfatase deficiency –> decreased CRH
Phase of parturition: Time when most events in labor and delivery happen
Phase 3
Most potent uterotonin
Oxytocin
3 important points at which oxytocin is increased
1) 2nd stage of labor
2) Early postpartum
3) Breastfeeding
Treatment of pregnant women with this agent in any gestation causes labor or abortion
PG
Substances that promote uterine contraction (4)
1) Platelet-activating factor
2) Endothelin-1
3) AT II
4) CRH, hCG, PTH-rp
Substance released with stripping of membranes
PGF-2α
Intrauterine tissue that provides tensile strength and resistance to tearing and rupture
Amnion
Intrauterine tissue that provides for immunological acceptance and is enriched with enzymes that inactivate uterotonins
Chorion laeve
Intrauterine tissue responsible for generation of uterotonins (paracrine) and responds to inflammatory reaction provoked by vaginal fluids
Decidua parietalis
Strict definition of labor
Uterine contractions that bring about demonstrable effacement and dilatation of the cervix
3 functional divisions of labor
1) Preparatory
2) Dilatational
3) Pelvic
Phase of labor: Latent phase
From perception of regular contractions to 3 cm dilation
Prolonged latent phase: Nullipara
> or = to 20 hours
Prolonged latent phase: Multipara
> or = 14 hours
Phase of labor: Affected by sedation or epidural analgesia
Latent phase
Phase of labor: Active phase
3 cm dilation to 10 cm dilation
Stages of labor
Stage I: Latent phase and active phase
Stage II
Stage III
Stage of labor: Stage II
10 cm dilation to delivery of neonate
Stage of labor: Stage III
Delivery of neonate to delivery of placenta
Normal duration: Active phase, multipara
Less than 4 hours
Normal duration: Active phase,nullipara
Less than 5 hours
Normal rate of cervical dilation during active phase: Multipara
> or = 1.5cm/hour
Normal rate of cervical dilation during active phase: Nullipara
> or = 1.2 cm/hour
Normal duration: Stage II, multipara
Less than 30 minutes
Normal duration: Stage II, nullipara
Less than 1 hour
Normal duration: Stage III (multipara and nullipara)
Less than 30 minutes
cm dilation wherein descent starts in nullipara
7-8 cm
True vs false labor: Contractions, regular
True
True vs false labor: Contractions, irregular
False
True vs false labor: Contractions, gradually shorten in duration
True
True vs false labor: Contractions gradually increase in intensity
True
True vs false labor: Pain/discomfort confined to lower abdomen
False
True vs false labor: Pain/discomfort at the abdomen and back
True
True vs false labor: Relieved by sedation
False
True vs false labor: Unaffected by sedation
True
Definition of “interval” between contraction
START of 1 contraction to the START of the next
Area of the abdomen where contraction starts
Fundus (not hypogastric)
Recpetors of oxytocin are more concentrated at which area of the uterus
Uterotubal junction
T/F Rest is ineffective in relieving true labor
T
Early vs late sign: Extrusion of mucus plug from the cervix, resulting in a bloody show
Early
Cervical effacement is expressed in terms of
Length of cervical canal compared to cervical canal of uneffaced cervix
Length of uneffaced cervix
2.5 to 3 cm
Cervical length is measured from
Lateral fornix to ectocervix
Normal biparietal diameter
9.5 cm, hence cervix should dilate 10 cm
Normal interspinous diameter
10 cm
Signals that the mother should START to push. (Do not ask to push before this happens)
1) Dilation at 10 cm 2) 2nd stage of labor 3) During contraction
Gestational age is ___ weeks before/after ovulation and fertilization
2 weeks before
Gestational age is ___ weeks before/after implantation
3 weeks before
Gestational age is aka
Menstrual age
Delivery may be more or less ___ weeks from EDD
+/- 2 weeks
Weeks from EDD at which pregnancy is considered postterm
> 2 weeks
Includes events in development from the time of ovulation (2 weeks after LMP)
Ovulation age or postconception age
Trimester: Spontaneous abortions
First
Trimester: BP is lower
Second
Period of organogenesis
Embryonic period
Emryonic period (week)
3rd week after ovulation
Event-week: Fetal blood vessels in chorionic villi appear
3
Event-week: Chorionic sac is 1 cm in diameter
3
Event-week: Chorionic sac is 2-3 cm in diameter
4
Event-week: Embryonic disc is formed
3
Event-week: Embryo is 4-5 mm in length
4
Event-week: Primitive heart
4-5
Event-week: Arm and leg buds
4-5
Event-week: Fingers and toes
6-8
Event-week: Arms bend at elbows
6-8
Event-week: Upper lip and external ears visible
6-8
Fetal period: AOG
10
T/F Fetal length is a more accurate criterion of gestational age than weight
T
Fetal weight increases linearly until ___ weeks
37
Weight gain of fetus in 3rd trimester
30g/day
Event-week: Centers of ossification appear
12 [CDB: 16]
Event-week: Gender can be determined by inspection of genitalia
14
Event-week: External genitalia – start to show evidence of gender
12
Event-week: Spontaneous fetal movements; responds to stimuli
12
Event-week: Downy lanugo hair surround skin
20
Event-week: Fetal breathing movements become regular
20
Event-week: Fat deposition begins
24
Event-week: Canalicular period of the lungs
24
Event-week: Fetal lung pneumocytes begin production of surfactant
24
Fetuses born at this time may survive w/ intensive neonatal care
24 weeks AOG
Event-week: Vernix caseosa
28
Event-week: Eyes partially open
28
Birth at this age: 90% survival w/ no physical or neuro impairment
28
Event-week: Testes start to descend
32
Sutures that can be palpated in vertex presentation
All except temporal
Junction of the lambdoid and temporal structures
Temporal/Caesarian fontanel
Occipitofrontal diameter
Most prominent part of occipital bone to root of nose
Widest transverse diameter of the fetal head
Biparietal diameter
Bitemporal diameter
Greatest distance between 2 temporal bones
Occipitomental diameter
Chin to most prominent portion of occiput
Suboccipitobregmatic diameter
Middle of anterior fontanel to undersurface of bone where it joins the neck
Shortest AP diameter that can pass through during normal cephalic delivery
Suboccipitobregmatic
Trachelobregmatic diameter
Bregma to undersurface of fetal mentum/mandible
Normal occipitofrontal diameter
11.5 cm
Normal bitemporal diameter
8 cm
Normal occipitomental diameter
12.5 cm
Normal suboccipitobregmatic diameter
9.5 cm
Normal trachelobregmatic diameter
9.5 cm
Greatest circumference of the head
Plane of the occipitofrontal diameter
Smallest circumference of the head
Plane of the suboccipitobregmatic diameter
Myelination of ventral roots of the cerebrospinal nerves and brainstem begins at
6th month
Major portion of myelination occurs
After birth
Fetal circulation
IMAGE
Medial vs lateral part of IVC: Well oxygenated blood
Medial
Medial vs lateral part of IVC: Less oxygenated blood
Lateral
Umbilical veins undergo atrophy and obliteration within ___ days
3-4
Ductus venosus constricts by
10-96 hours after birth
Ductus venosus anatomically closes at
2-3 weeks to become ligamentum venosum
Sites of EPO production in the fetus
Liver and kidneys
Hgb from yolk sac
Portland, Gower 1, Gower 2