O+g For GUM Flashcards
What is Mayer-Rokitansky-Kuster-Hauser syndrome
Müllerian agenesis - absent / rudimentary uterus + upper vagina.
Primary amenorrhea after normal pubertal development.
What age defines precocious puberty
Before 8 in F
Before 9 in M
2 categories of precocious puberty
Central (gonadotropin dependent - 75% cause unknown.)
Peripheral (always pathological)
Causes of central precocious puberty
75% unknown
25% due to CNS malformation or brain tumour
Causes of peripheral precocious puberty
Always pathological
Oestrogen secretion - e.g. Hormone producing tumour, exogenous ingestion
Age definition of delayed puberty
No secondary sexual characteristics
by age 13 In girls
14 in boys
Due to - hypogonadotrophic hypogonadism
- hypergonadotrophic hypogonadism
What causes hypogonadotrophic hypogonadism
Constitutional Anorexia nervosa Excessive exercise Diabetes Renal failure (Pituitary tumour, kalman's syndrome) - rare
What causes hypergonadotrophic hypogonadism
Turner syndrome
XX gonadal dysgenesis
Premature ovarian failure
Following chemo or radio therapy for child cancers.
What does gonadotropin releasing hormone do
Controls pituitary hormone secretion
GnRH secreted in a pulsatile way to stimulate LH and FSH
GnRH at constant high dose reduces LH and FSH secretion.
What is the effect of oestrogen on LH
Low oestrogen inhibits LH production.
High oestrogen increases LH production.
Effect of progesterone on LH and FSH
Low progesterone levels increase LH and FSH productions.
High progesterone levels decrease LH and FSH productions.
Causes of heavy menstrual bleeding
Fibroids Endometrial polyps Coagulation disorders PID thyroid disease Drug tx - warfarin Copper coil Endometrial ca Cervical ca
Management of heavy menstrual bleeding
Mefenamic acid (NSAID) Tranexamic acid Mirena coil COCP Norethisterone - taken from day 6 to 26 GnRH agonists - short term Endometrial ablation Hysterectomy
Causes of dysmenorrhea
Idiopathic Endometriosis Adenomyosis PID Cervical stenosis Haematometra
Diagnosis of endometriosis
laparoscopy - gold standard
often clinically suspected and managed without laparoscopic confirmation
Management options for endometriosis
COCP - continuous is best
IUS - Mirena / Levosert
Surgical laser ablation, diathermy or excision
Complication of endometriosis
Pain - dysmenorrhoea / dyaparunia
Adhesions
‘Chocolate’ ovarian cysts = endometriomas
possible increased risk of Infertility
What is adenomyosis
Ectopic endometrial tissue within myometrium
Management of dysmenorrhea
NSAIDS - ibruprofen, mefenamic acid COCP IUS - Mirena / Levosert Exercise Heat packs GnRH anaologues - short term only ?Low fat diet nay help
Causes of dyspareunia
PID Endometriosis Ovarian cysts STIs - CT most common cause Vaginal atrophy / lack of lubrication UTIs Thrush / vulvovaginitis / genital skin conditions / HSV (superficial dyspareunia)
Define primary amenorrhea
Failure to menstruate by age 16
Define secondary amenorrhea
Absence of menstruation for >6m that isn’t due to pregnancy, lactation or menopause
Causes of secondary amenorrhea
Obesity BMI <18.5 Excessive exercise Severe anxiety Pituitary tumour Chemotherapy Antipsychotic drugs Thyroid overactivity PCOS POI Ashermans syndrome
Causes of primary amenorrhea
Anatomical - cervical stenosis - imperforate hymen - Müllerian agenesis - transverse vaginal septum Hypothalamic-pituitary dysfunction - Anorexia - Chronic illness - excessive exercise - head injury Ovarian failure - Turners syndrome - POF - chemotherapy - pelvic irradiation Hypothyroidism Hyperthyroidism
Investigation of amenorrhea
Pregnancy test
Blood - LH, FSH - if premature menopause suspected
Prolactin level
TFT
USS of ovaries
Hysteroscopy if ashermans / cervical stenosis
Clinical manifestations of PCOS
Menstrual irregularity - oligomenorrhoea / amenorrhea Hirsutism Subfertility Recurrent miscarriage (50%) Obesity High LH insulin resistance Acanthosis nigricans
Diagnosis of PCOS
2 or more of:
- amenorrhea / oligomenorrhoea
- hyperandrogenism
- polycystic ovaries on USS
Management of PCOS
COCP - for endometrial protection, cycle regulation and contraception
OR Cyclical oral progesterone - for endometrial protection
Metformin
Clomiphene
Weight reduction
Exercise
Management of hirsutism
Eflornithine cream Cyproterone acetate (Dianette) Metformin GnRH analogues Laser / electrolysis
Causes of post menopausal bleeding
Atrophic vaginitis - 60% Endometrial polyps - 12% Endometrial hyperplasia - 10% Endometrial carcinoma - 10% Hormonal effects - 7% Cervical carcinoma - <1%
Investigation of post menopausal bleeding
TV USS of endometrial thickness (<3mm)
Endometrial biopsy
Hysteroscopy (+curettage of polyps)
Management of atrophic vaginitis
Topical oestrogen cream Oestrogen pessaries Oestrogen ring pessaries Vaginal moisturisers - daily use Vaginal lubricants for SI
Management of simple or complex endometrial hyperplasia (without atypia)
Oral progesterone
Mirena (NOT Levosert)
Usually regresses with progestogen treatment - needs monitoring
How can we explain endometrial hyperplasia to a patient
Endometrial hyperplasia is when the endometrium, the lining of the womb, becomes too thick.
It is not cancer, but in some cases if we leave it it could become cancer of the lining of the womb (uterus)
Management of atypical endometrial hyperplasia
Total abdominal hysterectomy - risk of progression to malignancy
Management of endometrial cancer
Total abdominal hysterectomy + BSO + washing +/- adjuvant therapy
Management of pre-menstrual syndrome
Stress reduction Exercise Alcohol and caffeine reduction COCP / oestrogen patches / IUS SSRIs CBT GnRH analogues - short term GnRH analogues - long term with add back HRT continuous combined Hysterectomy + BSO
Causes of cervical excitation
Ectopic pregnancy
PID
gonorrhoea / CT
Drugs for heavy menstrual bleeding
Mefenamic acid Tranexamic acid Norethisterone day 15 or 19 - 26 Levornagesterel IUD Danazol
How frequent should HIV +Ve women have cervical smears?
Yearly.
Despite CD4 count
What is the recommended frequency of cervical smears for women aged 25-49?
3 yearly
What is the recommended frequency of cervical smears for women aged 50-64?
5 yearly
What is Sheehan syndrome
Intrapartum pituitary haemorrhage
Does smoking affect the menopause?
yes - earlier
Define postmenopausal bleeding
PV bleeding occurring at least 12 months after the cessation of menstruation
Causes of postmenopausal bleeding include
Vaginal atrophy Endometrial carcinoma Endometrial hyperplasia Cervical cancer Ovarian cancer Liver cirrhosis