NV

Question 1

What’s nonpbarmacologic Supplement taken ?

Answer 1

Ginger 500-1000mh divided to 3 - 4 doses

Question 2

What’s the symptoms for nausea and vomiting?

Answer 2

Diaphoresis - disinterest in surroundings - pallor- faintness - salivation

Question 3

What’s the signs for nausea and vomiting ?

Answer 3

Malnourishment - weight loss - dehydration

Question 4

What’s the chemoreceptors trigger zone ?

Answer 4

Sertoinin type3 5-HT3 - Neurokinin-1(NL1) - dopamine (D2 )

Question 5

Vestibular system stimulated by

Answer 5

Motion sickness

Question 6

Vestibularsystem rich in ?

Answer 6

Histamine + muscarinic chlonergic recepters

Question 7

What’s the difference btw simple and complex nausea and vomiting ?

Answer 7

Simple : does not detrimentally affect hydrate status, electrolyte balance, or weight

Complex :
electrolyte imbalance + dehydration, weight loss may occur

Question 8

What’s considered when choose medication for pregnancy?

Answer 8

Teratogenic effect

Question 9

Low serum chloride and elevated serum bicarbonate indicate for what?

Answer 9

Metabolic alkalosis

Question 10

True or false
Second generation effective in NV.

Answer 10

False ineffetive
First generation is effective

Question 11

Mention first generation antihistamine

Answer 11

Diphenhydramine - dimenhydrinate - meclizine

Question 12

Side effect of first generation Antihistamine

Answer 12

Drowsiness - blurred vision

Question 13

Side effect of anticholinergic

Answer 13

Sedation, visual disturbances, dry mouth, dizziness

Question 14

True or false
Can domperidone affect QT prolongation?

Answer 14

True

Question 15

What’s Side effect shared by metaclopramide and domperidone ?

Answer 15

Hyperprolactinemia + galactrorrhea + gynecomastia

Question 16

True or false
Metaclopramide has minimally cross BBB

Answer 16

False
Domperidone has minimally cross BBB

Question 17

Metaclopramide From which class of dopamine antagonist

Answer 17

Prokinetic

Question 18

Side effects of phenothiazine group ?

Answer 18

Sedative - orthostatic hypotention - EPS ( in chronic use )

Question 19

Which medication have risk of QT interval prolongation?

Answer 19

Haloperidol + domleridone + droperidol + sertonin antagonist ( ondasetron - dolasetron)

Question 20

Which class of medication can increase risk of peptic ulcer

Answer 20

Corticosteroids

Question 21

Which trimester of pregnancy should avoid NV medications ?

Answer 21

First trimester

Question 22

What’s SE of corticostroids in short term?

Answer 22

GI upset + anxiety + insomnia + hyperglycemia

Question 23

True or false
Palonsetron it very effective in delay CINV

Answer 23

True

Question 24

True or false
Can use Aprepitant alone

Answer 24

False
Use in combination with serotonin and corticostroid

Question 25

True or false Current guideline not recommend using olanzapine

Answer 25

False Recommend to use it as addition

Question 26

Which medication can cause oral cleft when given during the first trimester ?

Answer 26

Methylprednisolone Avoided in first trimester

Question 27

Before treatment NV what's the First step?

Answer 27

Management to identify the cause لازم اعرف شنو سبب NV

Question 28

True or false Cyclophosphamide less than 1.5mg/m2 is high emetogenic potential

Answer 28

False More not less Moderate if less than 1.5mg/m2

Question 29

A 55-year-old woman is receiving cisplatin-based chemotherapy for ovarian cancer. The patient is being treated as an outpatient and will be receiving chemotherapy in the morning. Her medical history includes hypertension, which is well-controlled with medication. She is not on any other medications that affect the QT interval. Question: What is the most appropriate pharmacotherapy regimen to prevent acute chemotherapy-induced nausea and vomiting (CINV) in this patient? A) Ondansetron alone B) Ondansetron + dexamethasone C) palonosetron + dexamethasone + aprepitant D) Metoclopramide + dexamethasone E) Dronabinol

Answer 29

C

Question 30

TRUE OR FALSE Using Lorazepam for anticipatory NV

Answer 30

True

Question 31

What's the medication use in low emetogenic risk ?

Answer 31

Dexamethsone or 5-HT antagonist

Question 32

What the medication use in moderate emetogenic risk?

Answer 32

Dexamethsone and 5-HT antagonist

Question 33

What's the Medications use in high emetogenic risk

Answer 33

Nk1 receptors antagonist + 5-HT antagonist + dexamethsone + olanzapine

Question 34

What's the medication used for High emetogenic risk

Answer 34

NK1 antagonist + 5-HT antagonist + dexamethsone + olanzepine

Question 35

Which the following medication have emetogenic risk A) oral contraceptive B) ifosfamide C) carboplatin D) B+C E ) all above is correct

Answer 35

E That reason give oral contraceptive before bedtime

Question 36

Mentiom medication have high emetogenic risk

Answer 36

Cisplatin -high dose cyclophosphamide 1.5mg/m2 - cyclophosphamide combined with anthracycline

Question 37

Mention medication moderate emetogenic risk

Answer 37

Lower doses of cyclophosphamide Ifosfamide Carboplatin

Question 38

What's the mean acute CINV

Answer 38

Within 24 hrs after chemotherapy

Question 39

What's the mean delay CINV

Answer 39

Greater than 24 hrs after chemotherapy

Question 40

True or false Female is low risk of CINV

Answer 40

False Female high risk

Question 41

The longest half life of serotonin antagonist

Answer 41

Palonosetron

Question 42

True or false somking status is high risk of NV

Answer 42

False Nonsomking

Question 43

True or false risk of PONV denpend on duration and type of surgery

Answer 43

True

Question 44

True or false Postoperative opioid incease risk of NV

Answer 44

True

Question 45

True or false Ondansetron should totally avoided in PNV

Answer 45

False It used in severe case PNV