NUTRITIONAL GI DISEASE Flashcards

1
Q

Haematinic deficinecies (iron, B12, folate) effects on the oral cavity

A

-Glossitis (smooth depapillated tongue -> Fe raw beefy red-> B12 folate)
-angular cheilitis and candidosis
-Recurrent oral ulceration (20% of ROU pt have haematinic deficiency)
-Burning mouth SYMPTOMS
-Patterson Kelly Syndrome -dysphagia
+reduced taste sensation
lead to premalignant lesions

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2
Q

What is Patterson Kelly Syndrome

A

-Females
-Fe deficiency anaemia
-post cricoid web (increasing risk of pharyngeal + oral carcinoma)
-> dysphagia
-glossitis - depapillation of tongue+soreness
this is a pre-malignant condition
-koilonychia

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3
Q

Oral features of alcoholism

A
  • Sialosis/Sialodenosis
  • Dental erosion secondary to acid reflux (normally palatally)
  • OSCC
  • Malnutrition
  • Liver cirrhosis = easy ecchymosis and yellow appearance in mouth and can be linked to platelet dysfunction(?)
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4
Q

What is Bulimia nervosa

A

-Repeated bouts of overeating and being engrossed with controlling body weight
repeated= 2+ week for 3 months

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5
Q

Clinical ft of bulimia nervosa

A
  • Weight is normal (due to purging)
  • repeated vomitting=hypokalaemia
  • Dental erosion (normally palatally)
  • Calluses on dorsum on the hand= Russells sign
  • ulcers on soft palate
  • angular chelitis
  • sialosos/sialodenosis
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6
Q

Acute necrotising ulcerative gingivitis (ANUG)

A
  • Non contagious anaerobic infection associated with prevotella and fusobacterium
  • Painful sloughing
  • ulcerative punched out interdental papilla
  • gingival bleeding
  • halitosis of ROTTEN HAY
  • sialorrhea (drooling)
  • in malnurished/immunocompromised patients this can spread to oral mucosa and skin =cancrum oris
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7
Q

Predisposing factors to ANUG

A
  • smoking
  • Viral respiratory infection
  • Poor OH
  • Malnutrition
  • low socioeconomic background
  • Immunodeficiency eg. HIV
  • Stress
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8
Q

Management of ANUG

A
  • OHI
  • Oral debridement
  • Oxidising mouthwash (Peroxyl) like in black hairy tongue
  • Periodontal assessment
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9
Q

Necrotising stomatitis - NOMA

A

-Malnourished/immunosuppressed children in developing countries
-putrid oral malodour
-rapid devastating necrotising destruction (ST/HT and orofacial tissue)
acute=oedema, necrotizing stomatitis, cheek perforation-> sepsis=death
chronic= fibrous scar, oral strictures, trismus, dental malposition, salivary incontinence

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10
Q

Reasons for NOMA +predisposing factors

A

BACTERIAL INFECTION

  • ANUG
  • anaerobic bacteria eg. fusobacterium prevotella

PREDISPOSING FACTORS

  • poor OH
  • Poverty
  • Debilitating diseases
  • Malaria
  • Malnutrition
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11
Q

Vitamin C/ascorbic acid deficiency

A

-also known as scurvy
-essential in collagen synthesis
-initially: cork screw hairs (hair follicles enlarge+keratosis)
within weeks: bv proliferation around hair follicles & interdental papilla = gingival hyperplasia + haemorrhage
tooth mobility+exfoliation
cuntaneous bleeding and purpura

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12
Q

Zinc deficiency

A
  • important in cell mediated immunity, hormone function, gene expression
  • ZN found in meat fish dairy
  • common in elderly
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13
Q

ZN deficiency clinical ft (other than orally)

A
  • alopecia
  • poor apetite+ diarrhea
  • poor wound healing
  • depression
  • growth retardation
  • male hypogonadism
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14
Q

clinical features of Zn deficiency (oral)

A
  • GEOGRAPHIC TONGUE/benign migratory glossitis
  • CANDIDA SUPERINFECTION
  • hypogeusia
  • angular chelitis
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15
Q

Benign migratory glossitis associations

A
  • ZN DEFICIENCY
  • allergies eg. hay fever
  • GI disorders
  • xs lithium
  • pregnancy
  • Type 1 diabetes melliuts
  • seborrheoic dermatitis
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16
Q

if hypogeusia is not due to Zn

A

do not give zn supplements

xs zn= increased copper excretion

17
Q

What is Coeliac disease

A
  • chronic inflammation of SI induced by gluten
  • malabsorbtion
  • diarrhoea
  • fatigue
  • anaemia (haemetinic deficiencies)
  • delayed presentation
18
Q

Coeliac disease oral lesions

A
  • ROU
  • DENTAL HYPOPLASIA
  • HAEMATINIC DEFICIENCIES -> glossitis, angular chelitis, candida, Burning mouth symptoms/ stomatitis
  • Exacerbation of LP
19
Q

Dental hypoplasia associated with

A

-coeliac disease

20
Q

ROU is associated with

A
  • Haematinic defiencies
  • Bechets disease
  • Coeliac disease+crohns disease- GIT diseases
21
Q

Crohns disease aetiology

A

also known as inflammatory bowel disease

aetiology unknow but probably: genetic environment and host immunity causing inflammation

22
Q

Crohns disease (Specific and non-specific lesions)

A

SPECIFIC LESIONS

  • cobblestoning of the oral mucosa
  • ulcerative fissures
  • mucosal tags
  • mucogingivitis
  • lip swelling w/ vertical fissures

NON-SPECIFIC LESIONS

  • pyostomatitis vegetans
  • angular chelitis
  • ROU
  • glossitis
  • lymphadenopathy
23
Q

Orofacial granulomatosis clinical features

A

granulomatous inflammation +labial swelling
lymphadenopathy (submandibular and cervical)
sensitive to benzoates (preservities)
angular chelitis
mucosal ulceration
-melkerson rosenthal syndrome

24
Q

Melkerson rosenthal syndrome

A
  • associated with patients with OFG
  • Fissured tongue
  • LMN palsy of CN7
25
Q

OFG management

A

elimination of diets eg. benzoates and cinammon
topical corticosteroids eg. betamethasone 500mcg soluble tablets
topical tacrolimus ointment 0.1%

26
Q

Peutz Jeghers syndrome

A

-Rare autosomal dominant syndrom
-Mutation in the LKB1 and ch19 coding for serine-threonine kinase (plays a role in apoptosis)
-melanotic macules around vermillion border and perioorally
+intra orally= these are benign
-Haemtomatous polyps colorectally + abdominal and rectal bleeding which increase malignancy risk