Nutrition And Aging DLA Parts 1 & 2 Flashcards
Life expectancy is… population is…
Increasing
Changing
How is nutrition an important determinant of overall health at any age?
- Longevity
- Physical health
- Cognitive function
- Vitality
- Quality of life
Longevity and health is…
often influenced genetically but can be managed by healthy choices and pharmaceuticals
The process of growing older…
• Reduction in production of vital energy
• Decline in cellular activity causing a reduction in
cell number and mitochondrial activity
• Interruption in membrane transport processes
• Reduction in enzymatic activity (liver’s role in eliminating metabolic waste)
• Reduction in core body temperature
• Biological age vs. chronological age:
What are the benefits of lower energy requirements?
- Energy requirements drop between third and ninth decade of life, up to 33%
- Decline in muscle mass universal
- Physical activities can slow this decline
- Muscle more metabolically active than adipose
- Loss of muscle mass accompanied by drop in basal metabolic rate
- deceased. 10 kg = decreased 150 kcal/d energy expenditure
- Decline in energy requirements and consuming less food can lead to protein and micronutrient deficiencies
What factors contribute to inadequate nutrition socioeconomically?
Fixed Income
Reduced access to food
Social isolation
Inadequate storage facilities Inadequate cooking facilities
Poor knowledge of nutrition
Dependence on others Caretakers Institutions
What factors contribute to inadequate nutrition in older adults physiologically?
Impaired strength/aerobic capacity
Impaired mobility/dexterity (arthritis, stroke) Impaired sensory input (smell, taste, sight) Poor dentition/oral health
Malabsorption
Chronic illness (via anorexia, altered metabolism)
Alcohol Drugs (eg, SSRIs,a NSAIDs,b digoxin, opiates, levodopa, antibiotics, metformin, iron, others)
What factors contribute to inadequate nutrition in older adults psychologically?
Depression
Bereavement
Anxiety, fear, paranoia
Dementia
What factors contribute to inadequate nutrition in older adults?
Failure to monitor dietary intake and record weights
Failure to consider increased metabolic requirements
Iatrogenic starvation (eg, NPOc for diagnostic tests)
Delay in instituting nutritional support
What changes in body systems associated with aging?
Skeletal muscle atrophy, Osteoporosis
Atherosclerosis, hypertension
Reduced cognitive function
Reduced lung volume, Obstructive pulmonary disease Non-insulin dependent diabetes, hypercortisolemia General decline in function especially T cells
What are the age related changes in body composition?
Weight increases (body fat) steadily from age 30-60 y
• After 60 y,
• weight stabilizes then declines
• Loss is mainly lean body mass
• muscle mass may decline up to 45% by the eighth decade of life (sarcopenia)
• Causes? Decline in:
- Fat metabolism
- Activity
- Protein synthesis capacity
- Hormones (testosterone, estrogen and insulin-like growth factors)
- Mitochondrial ATP production
What is protein energy malnutrition?
Insufficient energy and/or protein for metabolic needs
PEM most common deficiency in elderly persons caused by:
Inadequate intake
• reversible
Disease affecting metabolism, composition & appetite
• Called cachexia and may develop in older persons with no obvious cause
• Cachexia associated with chronic disease (cancer, infection, etc.) • Acute immune response
• Elevated inflammatory mediators
• Affects hormone production, control of metabolism and increase in resting energy
expenditure
• Muscle degradation may not be reversible
What is the impact of chronic inflammatory response?
Normally innate immune response is regulated by negative feedback when infection or injury is resolved
• Older persons often have ongoing low- grade activation of inflammatory processes
• Measured by modest elevations of serum levels of inflammatory signaling proteins.
• Associated with poor outcomes of
disability, cognitive decline, frailty,
sarcopenia, and early mortality.
What is the relation of aging process and oxidative stress?
Cellular defenses against oxidative damage decline with age
Reductions in the expression of genes and proteins associated with mitochondrial function and reduction of free radicals
Increased expression of those involved with pro-inflammatory response (like cytokines)
What is the relation between the aging process and anemia?
• Anemia is common in elderly, prevalence increases with age (CBC) • Typical symptoms attributable to advancing age
• Fatigue, weakness, shortness of breath (dyspnea)
• A cause is found in ~80% of elderly patients
• Most common causes (check size and shape of RBC):
• Chronic disease
• Iron deficiency* due to chronic gastrointestinal blood loss (microcytic) • NSAIDinducedgastritis,ulcer,coloncancer,diverticula
• Vitamin B12 deficiency (macrocytic) • Folate deficiency (macrocytic)
* Iron supplementation should be smaller doses than for younger population