Nutrition Flashcards
Fetal growth factors
Genetic-
Maternal-
Uterine size/circulation and placental implantation
Nutrition (delayed effects)
Endocrine increased in GH, GH-peptides (placental lactogen)
Placental-
What effect does placental lactogen have on fetal growth?
Relative insulin-resistance–>
Increased glucose and lipid concentrations–>
Increased fetal insulin–>
Increased fetal growth, adiposity, decreased protein breakdown
Mediated by IGF
What components of fetal composition decrease with gestational age and BW?
Total body water
Extracellular water
Sodium
Chloride
What components of fetal composition increase with gestational age and BW?
Intracellular water Protein Fat Calcium Phosphorus Magnesium Iron
What is the daily calorie expenditure of a fetus?
35-55kcal/kg/d
Where does the fetus get the majority of its energy source?
Maternal glucose 2/3 of fetal energy Transferred by facilitated diffusion ---> Glycolysis ---> Carbon source ---> Glycogen storage
What are the sources of caloric energy for the fetus?
Maternal glucose (2/3) Placental lactate (1/4) Maternal amino acids (remaining- transferred by active transport)
Essential amino acids
Lysine Phenylalanine Threonine Tryptophan Methionine Histidine Valine Leucine Isoleucine
Essential fatty acids are
Linoleic
Linolenic
LCPUFA’s are absorbed by
Reesterification
Chylomicron formation
Lymphatic transport by lipoproteins
S/MCFA are absorbed by
Hydrolyzed to FFA
Absorption across mucosa
A _____:______ ratio of _____ suggests fatty acid deficiency
Triene: tetrene ratio
> 0.4
The predominant carbohydrate in breast milk and most formulas is
Lactose
Transport of water soluble vitamins across the placenta is by
Active transport
Transport the fat soluble vitamins across the placenta is by
Simple or facilitated diffusion
Megaloblastic macrocytic anemia with hypersigmented neutrophils is caused by ____ deficiency
Vitamin B12 and folic acid
Vitamin B12 deficiency with anemia is associated with
Methylmalonic acidia
Homocystinuria
Vitamin E deficiency presents with
Hemolysis Anemia and reticulocytosis Thrombocytosis Acanthocytosis Neurologic deficits
Photophobia, conjunctivitis, abnormal epithelial bone formation, abnormal tooth enamel, scaling, failure to thrive are associated with ______ deficiency
Vitamin A
Fatigue irritability constipation cardiac failure (beriberi syndrome) are associated with ______ deficiency
Vitamin B1