Nutri Theraputics Flashcards
- Know how to interpret folate, B12, and iron deficiency anemias on blood chemistries and nutrient support for anemia.
• decreased transferrin saturation – in those with?
- Hemolytic anemia
- iron deficiency anemia
- macrocytic anemia
iron deficiency anemia
• megaloblastic anemia resulting from _____ deficiency is identical to the megaloblastic anemia resulting from _____ ___ deficiency, and further clinical testing is required to diagnose the true cause of megaloblastic anemia
- B12, B6
- B6, iron
- folate, B12
- folate, iron
folate, B12
Signs of what?
fatigue, poor balance memory loss, pallor (paleness), reduced sensation of touch, shortness of breath, or tingling feet
anemia
Megaloblastic or macrocytic anemia: can be classified by what kind of cells? what nutrients?
- B12, B6
- B6, iron
- folate, B12
- folate, iron
- enlarged, immature red blood cells
- enlarged, immature white blood cells
- shrunken, immature red blood cells
- sickle shaped cells
enlarged, immature red blood cells.
B12, or folate
Recommendations for:
• the DASH, Mediterranean or a full plant-based diet3 in order to help balance out his blood chemistry.
• Lower dietary sodium
• Increase water
• Increase plant based protein (pg112)
• Omega -3’s (pg114)
• Fiber, Alpha Lipoic Acid, CoQ10, garlic etc
- Know dietary and nutritional support for hypertension pg 105 - Week 2 Discussion Board A
What condition do these test for? • Homocysteine, • CoQ10, • alpha-tocopherol, • gamma- tocopherol, • lipid peroxieds • low vitamin C • CRP
cardiovascular health
two heavy metals associated with poor cardiovascular health
- aluminum, cadmium
- cadmium, lead
- lead, aluminum
cadmium, lead
T or F: RBC potassium is a better indicator of total body stores than serum potassium
True
Numerous research has demonstrated a significant reduction of blood pressure with increased dietary intake of ____. At ___ g per day
- biotin, 5.7
- folate, 5.7
- magnesium, 4.7
- potassium, 4.7
potassium, 4.7
A high dietary intake of 500 – 1000 mg per day of ____ reduces blood pressure in most of the clinical trials.
- calcium
- magnesium
- potassium
- sodium
magnesium
T or F: Body magnesium is more accurate in assessing total RBC magnesium
False , opposite
Adding 1000 – 2000 mg/d of _____ will enhance the anti-hypertensive effects of magnesium.
- Glycine
- Lysine
- Serine
- Taurine
taurine
T or F: High serum zinc levels have been associated with hypertension as well as cardiovascular disease
false, low
______ mcg of allicin (four cloves) is the required amount to have a significant effect on lowering blood pressure
- 100
- 1000
- 10,000
- 100,000
10,000
____ : decrease potassium, magnesium, phosphorus, sodium, chloride, folate, vitamin B6, zinc, iodine, and CoQ10.
- Beta blockers
- Diuretics
- PPI
- SSRI
Diuretics
_____ reduce CoQ10 and zinc
- Beta blockers
- Diuretics
- PPI
- SSRI
Beta Blockers:
5 statements required to be on dietary supplement labels
- Name of the dietary supplement
- Amount
- Nutrition labeling
- Ingredient list
- The name and place of business of the manufacturer, packer, or distributor
Vital for brain and organ function
- 25% of total _______ in the body is in the brain
- Required for the synthesis of steroid hormones
- Required to synthesize vitamin D
- Required to produce bile salts
- Cholesterol
- Chylomicron
- LDL
- Lipids
- VLDL
cholesterol
Mechanisms in which _____ induce vascular damage
- Inflammation
- Oxidative stress
- Autoimmune dysfunction
- None
- All
- A and B only
all
_____ and ____ have a positive effect on serum lipids and CHD risk.
- Monounsaturated and PUFAs
- Monounsaturated and Saturated
- PUFAs and n-3s
- PUFAs and saturated
Monounsaturated and PUFAs
\_\_\_\_\_ \_\_\_\_\_ contribute to: –Insulin resistance –Artherogenic LDL –LDL particle number –VLDL –Triglycerides –Total HDL and HDL subfractions
Refined carbohydrates
___ Particles Cause Plaque
•Cholesterol cannot float freely in the body
•Cholesterol is carried inside ___ particles through your blood.
- Cholesterol
- Chylomicron
- LDL
- Lipids
- VLDL
LDL
Expanded Lipid Panels looks at what 4 things?
LDL particle number
LDL small
LDL medium
LDL Large
How to Change Small ___ to Large ___
Exercise
–4-5 days per week for at least 30 minutes
–2 days per week, do weight training
•Nutrition
–Consume fish 2-3 times per week or take a fish oil supplement
–Plant Sterols (2,000 mg/day)
Small LDL to Large LDL
How to improve ____?
–Body fat loss
–Exercise
–Consume fish 2-3 times per week or take a fish oil supplement (3 - 5 g/d)
–Niacin (500 mg to 4000 mg in divided doses)
–Quit smoking
- Apo A
- Apo B
- Cholesterol
- HDL2B
- LDL
- VLDL
HDL2b
____ is a true measurement direct measurement of amount of LDL particles
•A high number of ____ increase your risk of heart disease
•____ is a direct measurement whereas LDL is a calculated number, so ____ is a better marker for disease risk
- Apo A
- Apo B
- Cholesterol
- HDL2B
- LDL
- VLDL
Apo B
How to improve ____?
Increase foods with plant sterols
–Decrease foods high in saturated and eliminate trans fat
–Increase soluble fiber
–Exercise
- Apo A
- Apo B
- Cholesterol
- HDL2B
- LDL
- VLDL
Apo B
____ fiber binds fatty acids, cholesterol and bile acids and prevents their absorption or reabsorption during circulation.
•____ fiber increases bile acid synthesis, creating a pathway for cholesterol excretion.
•Since insulin stimulates cholesterol and triglyceride synthesis, lowering insulin with fiber may lower blood lipids.
soluble fiber
most of the cholesterol found in serum is derived from intestinal reuptake of cholesterol that has been deposited into the intestine from the ____ and ____
- Gall bladder and kidney
- Liver and gall bladder.
- Liver and kidney
liver and gall bladder.
- High levels can increase your risk for heart attacks and strokes
- Diet and exercise have no significant affect on lowering abnormal values
- A high level of ___ can be genetic – Family members may consider testing to see if they are at risk
- Niacin
- High dose vitamin C
- Apo B
- HDL
- LDL
- Lp(a)
Lp(a)
3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (HMG CoA reductase inhibitors)
•_____ is synthesized in the same pathway as cholesterol; therefore also involves the HMG CoA reductase enzyme.
•Research suggests that some statin drugs decrease serum _____ levels by as much as 40%
CoQ10
\_\_\_\_ induced nutrient depletions: –CoQ10 –Carnitine –Vitamin E –Vitamin D –Omega-3 fatty acids –Selenium
Statin
Nutrients to Improve__________ (9)
- Fish Oil
- Niacin
- Tocotrienols
- Red Yeast Rice
- CoQ10
- Green Tea (EGCg)
- Garlic
- Plant Sterols
- Fiber
Dyslipdemia
It has a positive impact on all lipid fractions
–Lowers LDL, Lp(a), and triglycerides
–Raises HDL and increase the ratio of large/small particle LDL
- Biotin
- Folate
- Niacin
- Pantothenic acid
niacin
Research indicates that the two most potent forms of tocotrienols are ____ and ____
- alpha and delta
- delta and gamma
- gamma and alpha
delta and gamma
Benefits:
- Reduce oxidation of unsaturated lipids in cell membranes and lipoprotein particles.
- Reduce foam cell formation by reducing oxidation of LDL particles and reducing the surface expression of cellular adhesion molecules.
- Reduce the translation of HMG-CoA reductase mRNA as well as increasing the degradation of the enzyme post-transcriptionally
Recommended dose: 250 mg of gamma and delta ____ at night with food.
•The dosage is very important because increased dosing will induce its own metabolism and effectiveness
•Lower doses are not as effective
- Tocotrienols
- Garlic
- Green Tea (EGCG)
Tocotrienols
- Reduces intestinal cholesterol absorption
- Inhibits enzymes involved in cholesterol synthesis
- Deactivates HMG CoA reductase
- Fibrinolytic and anti-platelet activity
- Lowers blood pressure
- Reduces LDL
- Decreases coronary calcification
- Tocotrienols
- Garlic
- Green Tea (EGCG)
Garlic
What botanical?
- Protects LDL cholesterol from oxidation
- EpiGallo-Catechin-3-Gallate- one of the more extensively studied green tea polyphenols
- Can cause a small decrease in LDL levels and reduce platelet aggregation
- Reduces fatty acid gene expression
- Inhibits HMG CoA reductase
- Decreases APO B lipoprotein secretion from cells
- Dosage: 500 – 700 mg/d
- Tocotrienols
- Garlic
- Green Tea (EGCG)
Green Tea (EGCg)
Dietary Recommendations for \_\_\_\_\_ •Reduce or eliminate refined carbohydrate intake •Anti-inflammatory diet •Avoid hydrogenated vegetable oils •Increase dietary fiber •Eat garlic often •Cook with coconut oil •Add olive oil to cooked foods and raw vegetables
dislyipidemia
Congestive heart failure. Issue with ____ ____. Restrict intake to _ _____ a day .
fluid retention, 2 quarts
• ____ foods further increase fluid retention, may lead to increased blood pressure
- Processed
- Whole
- Raw
- Macrobiotic
Processed
CHF patients are commonly deficient in what two minerals?
- calcium and sodium
- chloride and magnesium
- magnesium and potassium
magnesium and potassium
diuretic mediation often deplete what two minerals?
- calcium and sodium
- chloride and magnesium
- magnesium and potassium
magnesium and potassium
three non mineral nutrients often needed in CHF.
- d-ribose, CoQ10, L – carnitine
- d-ribose, CoQ10, L – lysine
- d-ribose, CoQ10, L – phenylalanine
- d-ribose, CoQ10, L – serine
d-ribose, CoQ10, L - carnitine
• GI – 4Rs
o Remove food sensitivities or allergies, alcohol, aspirin, NSAIDS from the diet. Use antimicrobials for dysbiosis or GI infection
o Replace digestive enzymes and HCL if necessary.
o Reinoculate the bowel with pre- and probiotics.
o Repair the GI mucosa
What supplement ?
• Protects the intestinal epithelial cells and supports intestinal barrier function.
• Increases sIgA secretion
• Directly inhibits colonization of harmful bacteria
• protects gastrointestinal tract during antibiotic therapy
• Restores normal intestinal function in children and adults with diarrhea
• Prevents traveler’s diarrhea
• C. difficile
• Inflammatory Bowel Disease
• Use with GERD
• A nonpathogenic, probiotic yeast.
- Bifidobacterium breve
- Bifidobacterium infantis
- Lactobacillus
- Saccharomyces boulardii
• Saccharomyces boulardii