NUR 325: Hyperlipidemia Flashcards
What is the MOA of atorvastatin? (& pronounce)
Inhibits HMG-CoA reductase so less cholesterol is produced by liver and liver makes more LDL receptors to pull LDL from the blood.
What are the adverse reactions with HMG-CoA Reductase Inhibitors?
Myopathy
Rhabdomyolysis
Hepatotoxicity
What time should HMG-CoA reductase inhibitors be taken?
Most are taken at night since that is when the liver produces cholesterol.
What is the MOA of ezetimibe? (& pronounce)
Blocks absorption of cholesterol in jejunum
What are adverse reactions with ezetimibe?
Headache
Myalgia & arthralgia
Abdominal pain
Diarrhea
MOA of atorvastatin (Lipitor)
Inhibiting HMG-CoA reductase
Less cholesterol is produced by liver
Liver makes more LDL receptors
More LDL is removed from the blood
Not making as much cholesterol
Removing more LDL from the blood
NOT A PERMANENT DROP IN LEVELS
Need to keep taking the drug
Stabilize plaque and decrease inflammation
MOA of simvastatin (Zocor)
Inhibiting HMG-CoA reductase
Less cholesterol is produced by liver
Liver makes more LDL receptors
More LDL is removed from the blood
Not making as much cholesterol
Removing more LDL from the blood
NOT A PERMANENT DROP IN LEVELS
Need to keep taking the drug
Stabilize plaque and decrease inflammation
MOA of rosuvastatin (Crestor) - & pronounce
Inhibiting HMG-CoA reductase
Less cholesterol is produced by liver
Liver makes more LDL receptors
More LDL is removed from the blood
Not making as much cholesterol
Removing more LDL from the blood
NOT A PERMANENT DROP IN LEVELS
Need to keep taking the drug
Stabilize plaque and decrease inflammation
Adverse reactions of atorvastatin, simvastatin, rosuvastatin
- Myopathy
- Rhabdomyolysis
- Breakdown of muscle fibers
- Acute kidney failure
- Hepatotoxicity
Other meds used to treat HLD
Bile acid sequestrants
cholestyramine (Questran)
Niacin
Fibric acid derivative (Fibrates)
Fish oil
