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ABNM CE > Nucs Mechanism of Localization > Flashcards

Nucs Mechanism of Localization Flashcards

1
Q

Passive Diffusion

A
  • Tc-Sestamibi - Cross the cell membrane via lipophilic diffusion
  • Tc-Tetrofosmin - Cross the cell membrain via lipophillic diffusion
  • Tc-HMPAO - Delivery is flow related - then diffuse into the brain
  • Tc-ECD - Delivery is flow related - then diffuse to brain
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2
Q

Filtration

A

DTPA

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3
Q

Facilitated Diffusion

A

F18 - FDG

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4
Q

Active Transport

A
  • I-123/I-131 (use ATP to move AGAINST concentration gradient)
  • Thallium (Na/K Pump)
  • Rubidium (Na/K Pump)
  • MIBG (Na facilitated NE uptake system)
  • DMSA
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5
Q

Secretion

A
  • Pertechnetate (active transport out of gland or tissue)
  • MAG-3 (gets “threecreated” by peritubular capillaries)
  • Tc-99m IDA (secreted by hepatocytes)
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6
Q

Phagocytosis

A

Sulfur colloid (RES ears colloid particles)

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7
Q

Sequestration

A

Head Treated RBCs

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8
Q

Capillary Blockade

A

MAA (lung perfusion)

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9
Q

Chemisorption

A
  • MDP (Chemical covalent + H-bonding)
  • SM-153
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10
Q

Cellular Migration

A

In-WBC

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11
Q

Receptor Binding

A
  • Octreotide
  • Ga-68 DOTATATE
  • DAT Scan (I-123 Isoflupane)
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12
Q

Tc-99m Medronate (MDP)

A

Phosphate analogue

“Chemisorption” - binds with hydroxyappetitie on the boner surface

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13
Q

F-18

A

Glucose analogue

Facilitated diffusion and secondary active transport

trapped in cell via phosphorylation till F18 decays

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14
Q

I123 and I131

A

Iodine analogue

Actively transported into the cell by the Na/I symporter (NIS)

Incorporated into the Thyroid Hormone

Absorbed via GI

“NIS is located at the basolateral membrane of the thyroid follicular cells”

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15
Q

Tc-99m Pertechnetate

A

Iodine analoge (for thyroid scans anyways)

Actively transported by the NIS

NOT incorporated into thyroid hormone

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16
Q

Thallium 201

A

K analogue

Na/K ATP pimp

Active transport

17
Q

Indium 111

A

WBC analogue (when tagged to PMNs)

localized via the WBC chemotaxis, the uptake occurs via phagocytosis

Indium oxine is lypophillic so it will passively cross cell membrane

18
Q

Tc-99m HMPOA

A

Crosses the BBB first pase cuz it begins its journey as liphophillic and then can’t diffuse out

19
Q

Tc-99m ECD

A

Same as HMPOA but has more rapid clearance from the blood pool

20
Q

Tc-99m-Sestamibi

A

Has fetish for Mitochondrial Membranes

Lipophillic cationic molecule that passively diffuses into cell then lathces onto the negatively charged meti membranes

21
Q

MIBG

A

NE analogue

Active uptake via NE transporter and passive diffusion

Stored in neurosecretory granules

22
Q

Indium-111 pentotreotide

A

Somatostatin analogue

Recepter binding

type 2,3,5

23
Q

Galium 67

A

Iron analogue

Trensferrin and lactoferrin receptor binding

acute phase reactant

ABNM CE (12 decks)

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