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Biochemistry > Nucleotides > Flashcards

Nucleotides Flashcards

1
Q

Monomer units or building blocks of nucleic aids

A

Nucleotides

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2
Q

Sugar+ Purine or Pyrimidine

A

NucleoSIDE

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3
Q

Bond in nucleosides

A

B-N-glycosidic bond

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4
Q

Nucleosides with a phosphoryl group esterified to a hydroxyl group of the sugar

A

NucleoTIDES

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5
Q

Most nucleotides have a phosphoryl group attached to what Carbon?

A

Carbon 5 (5’-nucleotides)

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6
Q

Catalyze the hydrolysis of phosphodiester bonds

A

Phosphodiesterases

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7
Q

Sources of atoms in purine synthesis

A

Aspartic acid, Glycine, Glutamine, CO2, N10-formyltetrahydrofolate and N5, N10 methenyltetrahydrofolate

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8
Q

Sources of atoms in pyrimidine synthesis

A

Glutamine, aspartic acid, carbon dioxide

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9
Q

Nucleotide not found in DNA

A

Uracil

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10
Q

Nucleotide not found in RNA

A

Thymine

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11
Q

Bond that holds 2 nucleotides together

A

Phosphodiester bond

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12
Q

Sources of atoms for both purine and pyrimidine

A

Glutamine, aspartic acid

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13
Q

Atoms source exclusively for purine synthesis

A

Glycine, N10-formyltetrahydrofolate, and N5N10 methenyltetrahydrofolate

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14
Q

Enzyme for PRPP syntesis

A

PRPP synthase

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15
Q

Enzyme for 5’-phosphoribosylamine

A

Glutamyl PRPP amidotransferase

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16
Q

Committed step in purine nucleotide biosynthesis

A

5’-phosphoribosylamine

17
Q

Base of inosine monophosphate

A

Hypoxanthine

18
Q

Parent purine nucleotide

A

Inosine monophosphaye

19
Q

AMP synthesis requires what molecule?

20
Q

GMP synthesis requires what molecule?

21
Q

Source of ribose 5’-P

22
Q

Irreversible Enzymes

A

APRT, HGPRT

23
Q

Regulated and rate limiting step in pyrimidine synthesis

A

Synthesis of Carbamoyl phosphate

24
Q

Parent pyrimidine nucleotide

A

Orotidine monophosphate

25
Q

OMP is converted to UMP by what enzyme

A

OMP decarboxylase

26
Q

Enzyme in synthesis of dTMP from dUMP

A

Thymiylate synthase

27
Q

Salvageable pyrimidines

A

Uridine,cytidine, deoxycytidine, thymidine

28
Q

Enzyme necessary for synthesis of deoxyribonucleotides

A

Ribonucleotide reductase

29
Q

Regeneratea the reduced form of ribonucleotide reductase

A

Thioredoxin

30
Q

Dietary purines are generally converted to?

31
Q

Precursor for uric acid?

32
Q

Responsible for xanthine to uric acid rxn

A

Xanthine oxidase

33
Q

Products of pyrimidine degredation

A

B-alanine,B- aminoisobutyrate

34
Q

Succinyl coA precursor

A

B- aminoisobutyrate

35
Q

Acetyl CoA precursor

36
Q

Structural analogs of PABA that competitively inhibit bacterial synthesis of folic acid

A

Sulfonamides

Biochemistry (8 decks)

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