Nucleotides

Question 1

Monomer units or building blocks of nucleic aids

Answer 1

Nucleotides

Question 2

Sugar+ Purine or Pyrimidine

Answer 2

NucleoSIDE

Question 3

Bond in nucleosides

Answer 3

B-N-glycosidic bond

Question 4

Nucleosides with a phosphoryl group esterified to a hydroxyl group of the sugar

Answer 4

NucleoTIDES

Question 5

Most nucleotides have a phosphoryl group attached to what Carbon?

Answer 5

Carbon 5 (5’-nucleotides)

Question 6

Catalyze the hydrolysis of phosphodiester bonds

Answer 6

Phosphodiesterases

Question 7

Sources of atoms in purine synthesis

Answer 7

Aspartic acid, Glycine, Glutamine, CO2, N10-formyltetrahydrofolate and N5, N10 methenyltetrahydrofolate

Question 8

Sources of atoms in pyrimidine synthesis

Answer 8

Glutamine, aspartic acid, carbon dioxide

Question 9

Nucleotide not found in DNA

Answer 9

Uracil

Question 10

Nucleotide not found in RNA

Answer 10

Thymine

Question 11

Bond that holds 2 nucleotides together

Answer 11

Phosphodiester bond

Question 12

Sources of atoms for both purine and pyrimidine

Answer 12

Glutamine, aspartic acid

Question 13

Atoms source exclusively for purine synthesis

Answer 13

Glycine, N10-formyltetrahydrofolate, and N5N10 methenyltetrahydrofolate

Question 14

Enzyme for PRPP syntesis

Answer 14

PRPP synthase

Question 15

Enzyme for 5’-phosphoribosylamine

Answer 15

Glutamyl PRPP amidotransferase

Question 16

Committed step in purine nucleotide biosynthesis

Answer 16

5’-phosphoribosylamine

Question 17

Base of inosine monophosphate

Answer 17

Hypoxanthine

Question 18

Parent purine nucleotide

Answer 18

Inosine monophosphaye

Question 19

AMP synthesis requires what molecule?

Answer 19

GTP

Question 20

GMP synthesis requires what molecule?

Answer 20

ATP

Question 21

Source of ribose 5’-P

Answer 21

PRPP

Question 22

Irreversible Enzymes

Answer 22

APRT, HGPRT

Question 23

Regulated and rate limiting step in pyrimidine synthesis

Answer 23

Synthesis of Carbamoyl phosphate

Question 24

Parent pyrimidine nucleotide

Answer 24

Orotidine monophosphate

Question 25

OMP is converted to UMP by what enzyme

Answer 25

OMP decarboxylase

Question 26

Enzyme in synthesis of dTMP from dUMP

Answer 26

Thymiylate synthase

Question 27

Salvageable pyrimidines

Answer 27

Uridine,cytidine, deoxycytidine, thymidine

Question 28

Enzyme necessary for synthesis of deoxyribonucleotides

Answer 28

Ribonucleotide reductase

Question 29

Regeneratea the reduced form of ribonucleotide reductase

Answer 29

Thioredoxin

Question 30

Dietary purines are generally converted to?

Answer 30

Uric acid

Question 31

Precursor for uric acid?

Answer 31

Xanthine

Question 32

Responsible for xanthine to uric acid rxn

Answer 32

Xanthine oxidase

Question 33

Products of pyrimidine degredation

Answer 33

B-alanine,B- aminoisobutyrate

Question 34

Succinyl coA precursor

Answer 34

B- aminoisobutyrate

Question 35

Acetyl CoA precursor

Answer 35

B-alanine

Question 36

Structural analogs of PABA that competitively inhibit bacterial synthesis of folic acid

Answer 36

Sulfonamides