General Flashcards

0
Q

What does the Michaelis menten equation describe

A

How rxn velocity varies with substrate concentration

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1
Q

How do enzymes work

A

Lower free energy of activation

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2
Q

MM kinetics follow a ___ curve?

A

Hyperbolic curve

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3
Q

What are factors wc can affect the rxn rate

A

Substrate conc, temp, pH

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4
Q

Lineweaver burke plot is used for

A

Calculated Km and Vmax; determines mechanism of action of enzyme inhibitors

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5
Q

Precursor of arachidonic acid

A

Linoleic acid

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6
Q

Alcohol+ diacylglycerol/ spingosine via phosphodiester bond

A

Phospholipid

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7
Q

Spingosine and Fatty acid

A

Ceramide

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8
Q

Ceramide and gluctose or galactose

A

Cerebroside

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9
Q

Ceramide and oligosaccharide

A

Globosidr

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10
Q

Ceramide and N acetylneuramic acid

A

Ganglioside

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11
Q

Ceramide and sulfated galactose

A

Sulfatides

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12
Q

3 main kinds of eicosanoids

A

Porstaglandin, thromboxane, leukotrienes

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13
Q

Amino acid structure

A

Caboxyl, amino group, unique side chain

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14
Q

Smallest amino acid

A

Glycine

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15
Q

Largest amino acid

A

Tryptophan

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16
Q

Amino acid used in the 1st step of heme synthesis

A

Glycine

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17
Q

Major inhbitory NT in spinal cord

A

Glycine

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18
Q

AA that carries N from peripheral tissues to the liver

A

Alanine

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19
Q

Precuror of niacin, serotonin and melatonin

A

Tryptophan

20
Q

Precursor for homocysteine

A

Methionine

21
Q

An imino acid

22
Q

To cysteines form

23
Q

Major carrier of nitrogen from the peripheral tissues to the liver

24
Precursor for GABA and glutathione
Glutamate
25
Used in diagnosis of folic acid deficiency
N- formiminoglutamate excretion test
26
Precursor of creatinine, urea and nitric oxide
Arginine
27
All amino acids are chiral except for
Glycine
28
Chemical compound that has a total net charge of zero
Zeitteriob
29
Condotionally non essential amino acids
Arginine, histidine
30
Most common secondary structure of proteins
Alpha helix
31
Minor transporternof hgb in bloof
Hemoglobin (carbaminoHb)
32
HgB form with high oxygen affinity? Taut or Relaxed
Relaxed
33
Heme protein in heart and skeletal muscle
Myoglobib
34
Curve followed by Hgb
Sigmoidal
35
Deoxy form of HgB has a greater affinity for protons than does oxyhemoglobin
Bohr effect
36
Stabilizes T structure of Hgb by forming additional salt bridges that must be broken prior to conversion to the R state
2,3 BPG
37
Oxidized form of Hgb (Fe3)
Methemoglobin
38
Chocolate cyanosis
Methemoglobinemia
39
Most abundant protein in body
Collagen
40
Most common form of collagen
Type I
41
Amino acid sequence of collagen
Gly-X-Y ; x: proline= kinking; y: hydroxyproline or hydroxylysine
42
HCl is produced by what cells
Parietal cells
43
Pepsinogen is produced by
Chief cells
44
All amino acids must transfer their amino groups to a ketoglutarate to from GLUTAMATE except
Lysine and threonine
45
Coenzyme in transamination
Vit B6
46
Removal of excess N from peripheral tissues is via
glutamine, alanine, glutaminase
47
Also known as the Krebs Henseleit Cycle/ Ornithine cycle
Urea cycle