Nucleotide Metabolism Flashcards

1
Q

Rate limiting step in pyrimidine synthesis

A

ATCase

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2
Q

Inhibits ATcase

A

CTP

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3
Q

Stimulates ATcase

A

ATP

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4
Q

Inhibits conversion of IMP to guanosine derivatives-Treats cancer

Binds more tightly to folate than folic acid (acts as competitive inhibitor)

A

Methotrexate

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5
Q

Inhibits conversion of UMP to Thymidine-Used to treat cancer

A

5 Fluorouracil

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6
Q

Antiviral drug that resembles guanine. Viral TK converts this drug, which becomes a surrogate for GTP and is incorporated into rapidly dividing viral cells. Leads to termination of DNA replication. Treats herpes zoster and chickenpox

A

Acyclovir

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7
Q

Catabolism makes succinyl and malonyl coA

A

Pyrimidine

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8
Q

Caused by overproduction of uric acid. Treated by allopurinol

A

GOUT

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9
Q

Mechanism of action is to inhibit xanthine oxidase

A

Allopurinol

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10
Q

Salvage pathway that involves TK (DTTP)

Produces UTP from uracil

A

Pyrimidine Salvage Pathway

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11
Q

Salvage pathway that makes AMP from Adenine and GMP and IMP from Guanine and Hypoxanthine

VIA HGPRT

A

Purine Salvag pathway

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12
Q

Defect in HGPRT; can’t make IMP or GMP; leads to accumulation of uric acid; High levels of hypoxanthine and guanine shunted towards uric acid instead of being used in the salvage pathwayMental retardation and self mutilation

A

Lesch-Nyhan

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13
Q

Rate limiting enzyme in purine synthesis and what step?

A

Glutamine

Converting PRPP to PRA

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14
Q

Rate limiting enzyme in pyrimidine synthesis and what step?

A

ATCase

Converting Carbonyl phosphate to carbonyl aspartate

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