Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MCM > Carbohydrate Metabolism > Flashcards

Carbohydrate Metabolism Flashcards

1
Q

Low Km and Low Vmax; inhibited by G6P

A

Hexokinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

High Km and high Vmax; inhibited by F6P

A

Glucokinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Inhibitors of PK (pyruvate kinase)

A

ATP, Glucagon, Alanine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Stimulators of PK (pyruvate kinase)

A

Insulin, F1-6 BP; dephosphorylation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Defects in glycolytic enzymes (such as PK, phosphoglucoisomerase and triosephosphate isomerase) malfunction of ATP pumps, intracellular NA+ concentration increases, cell swells, and bursts

A

Hemolytic anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Malfunction of GLUT 2; Impaired transport of fructose, glucose and galactose; fasting hypoglycemia

A

Fanconi Bickel

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Deficiency in PFK 1 (rate limiting enzyme of glycolysis)

A

Tauri Disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Rate limiting enzyme of gluconeogenesis

A

Fructose 1, 6 Bisphosphatase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Steps in Gluconeogenesis different from glycolysis

A

Pyruvate-Phosphoenolpyruvate (Pyruvate Carboxylase) and (PEPCK) OAA to PEP
Fructose 1,6 BP-Fructose 6P (Fructose 1,6 Bisphosphatase)
Glucose 6 Phosphate-Glucose (Glucose 6 Phosphatase)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Positive enzymatic regulators of gluconeogenesis

A

Malate Dehydrogenase; PEPCK, Pyruvate carboxylase, and fructose 1,6 bisphosphatase, glucose 6 phosphatase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Positive regulators of gluconeogenesis

A

Citrate, cortisol, thyroxine, acetyl coA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Negative regulators of gluconeogenesis

A

ADP, AMP, Fru 2-6 BP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Fructose 1,6 BP Deficiency

A

Can’t convert Fructose 1,6 BP to Fructose 6 Phosphate
Hypoglycemia
Lactic acidosis
Ketosis
Hyperventilation after artificial sweeteners

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Deficiency in glucose 6 phosphatase

Fasting hypoglycemia

A

Von Gierke Disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Fructose Metabolism

A

Usually used for fatty acid synthesis

Converted to sorbitol (sorbitol dehydrogenase) and to glucose (aldol reductase)-used for glycolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Galactose metabolism

A

GALT-rate limiting enzyme (converts Galactose 1 phosphate to Glucose 1 phosphate); in liver can convert to glucose 6 phosphate

17
Q

Deficiency in GALT; can cause cataracts

A

Galactosemia

18
Q

Regenerates glutathione (important in detoxifying H2O2)

A

NADPH (made from PPP)

19
Q

Inhibits glycogen breakdown

A

Insulin, GLUT 4, PKB, GSK3

20
Q

Stimulates glycogen breakdown

A

G protein, cAMP, PKA, PP1, PPK

21
Q

Defective glycogen synthase

A

GSD0

22
Q

Defective acid maltase

Can’t lysosomally degrade glycogen

A

Pompe (GSD II

23
Q

Deficiency in debranching enzyme

Light hypoglycemia and hepatomegaly

A

GSD III/ CORI

24
Q

Deficient branching enzyme
Cirrhosis
Death by age 5

A

GSD IV/ Andersen

25
Q

Deficiency in muscle glycogen phosphorylase

Exercise intolerance

A

GSD V/ MCARDLE

26
Q

Deficiency in liver glycogen phosphorylase

A

GSD VI/ HERs

MCM (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions