Nucleotide met Flashcards
degradation pathway
DNA/RNA -> denatured nucleotide -> oliconucleotide -remove PPD-> nucleotide -nucleotidase (remove P)-> nucleoside -nucleosidase (remove base) -> sugar
Pyrimidine pathway (products)
FAcoa -> malonyl -> ,slonyl semialdehyde -> beta-urido.. -> dihydrouracil -> uracil -> (salvage) -> cytocine
Pentose biosyn starter
hexose
Pentose syn pathwya
Pentose phosphorylation pathway -> PRPP -> pentose
Pyrimidine biosyn starter
Glutamine
Pyrimidine biosyn pathway
Glumatmine + hco3 - > carbomoid phosphate -> carbomoid aspartate -> dihydrorotate -> orotate - omp -> gmp -> utp (can be used as regulatory =)
Salvage pathway
PRPP -> Amp
PRPP -HRGPP-> I/gmp
UTP can be changed into
CTP
ATP can change GMP to
GDP and then GTP
adding ATP will
decrease ATP to ADP and increases the substrate by 1 P
what is PRPP
sugar
whats deoxy used for
DNA
ribonucleotide function
add P into the sugar to convert ribo to deoxyribo
ribo is OH or H
OH
glutathione is a carrier of
NADPH
thymidylate synthase function
dUMP -> dTMP
for dTMP to be produced, the simplified pathway is to
add methyl then recycle
for dTMP to be produced, the simplified pathway is to
add methyl then recycle
for dTMP to be produced, the simplified pathway is to
add methyl then recycle
purine syn pathways can be broken down into
salvage and de novo
salvage pathway
ribose-5-phosphate -> PRPP
de novo pathway
IMP -> AMP and GMP
