Nucleosomes Flashcards
1
Q
how big is human DNA?
A
human DNA is less than or equal to 1 meter
2
Q
how big is the nucleus?
A
5-10 mm
3
Q
How is DNA folded?
A
DNA folded into a package almost a million times smaller
4
Q
what are nucleosomes?
A
histone proteins with ~200 base pairs of DNA
“Bead on a string”
5
Q
Nucleosomes are proteins that are what?
A
proteins are clustered at 200 bp intervals along the DNA molecule in chromatin fibers
6
Q
what does the nucleosome structure consist of?
A
eight histone molecules (octamer)
2 each of: H2A, H2B, H3, H4
146 bp DNA making two turns
50 bp Linker DNA
7
Q
what is the bead diameter of a nucleosome?
A
bead diameter of 10 nm
8
Q
what is thought to bind to linker DNA
A
histone, H1
