Nucleic Acids - Yr 1 Flashcards
DNA
Deoxyribonucleic acid which is present in nearly all living organisms as the carrier of genetic information. A double helix made up of two polynucleotide chains, running antiparallel to each other, with the sugar-phosphate backbone on the outside and organic bases bonded together by Hydrogen bonds in the centre of the helix. The nucleotides have a deoxyribose sugar and the bases adenine, thymine, guanine or cytosine.
Nucleotide
Complex chemicals made up of an organic base, a sugar and a phosphate. They are the basic units of which the nucleic acids DNA and RNA are made.
Polynucleotide
A polymer of monomers called nucleotides.
Phosphodiester bond
The bond formed by a condensation reaction between the phosphate group of one nucleotide and the pentose sugar of another nucleotide.
Organic base
Part of a nucleotide - either adenine, thymine, cytosine, guanine or uracil.
RNA
A polynucleotide which contains nucleotides that have the pentose sugar ribose rather than deoxyribose and contains the bases adenine, uracil, guanine or cytosine. Can be either mRNA, tRNA or rRNA.
Complimentary base pairing
Specific rules for how the bases pair together. Adenine pairs with thymine with 2 hydrogen bonds. Guanine binds with cytosine with 3 hydrogen bonds.
Double helix
Structure of DNA made up of 2 strands of nucleotides running in opposite directions.
Semiconservative replication
The process in which the double helix of a DNA molecule unwinds and each strand acts as a template on which a new strand is constructed.
DNA helicase
Enzyme that acts on a specific region of the DNA molecule to break the hydrogen bonds between the bases causing the two strands to separate and expose the nucleotide bases in that region
DNA polymerase
Enzyme that joins DNA nucleotides together in a condensation reaction (forming phosphodiester bonds) during DNA replication.
ATP (Adenosine triphosphate)
An activated nucleotide found in all living organisms, which is produced during respiration and acts as an energy carrier. The hydrolysis of ATP (catalyzed by ATP hydrolase) leads to the formation of adenosine diphosphate (ADP) and inorganic phosphate, with the release of energy.
ADP
A nucleotide which combines in a condensation reaction, catalysed by ATP synthase, with a phosphate molecule to form ATP.
ATP Synthase
An enzyme which catalyses the formation of ATP.
ATP Hydrolase
An enzyme which catalyses the hydrolysis of ATP.