Nuclear Radiochemistry

Question 1

What are the two basic components needed for nuclear medicine imaging?

Answer 1

Source of gamma radiation

Ligand: to carry radiation thing to the organ

Question 2

What’s required of a radioactive nucleide for use in nuclear medicine imaging?

Answer 2

gamma radiation (preferable > 50keV)

Half life long enough for distribution, short enough to image

Able to go to the organ

Question 3

What is the main element used for nuclear medicine imaging?

Answer 3

Technitium

Question 4

Why is technitium so good for nuclear medicine imaging?

Answer 4

half-life just 6 hours

ideal gamma-ray energies for imaging

Question 5

What element is used the most in PET?

Answer 5

Flouride

Question 6

How can radionuclides be produced (3)?

Answer 6

Naturally occurring
Bombardement
Generator produced

Question 7

What properties are required for a ligand for nuclear medicine imaging?

Answer 7

• Stable
  - Labelling should not affect ligand accumulation in the organ
  - The product should be retained in the organ
  - Product should not leak out form cells
  - Tissue uptake should be specific

Question 8

What states can ligands/ radionuclides be administered in?

Answer 8

Soluble
Particulate
Gaseous