NU625 Test 1 Trial 2 Flashcards
What is? The basic cellular unit of the nervous system, the microprocessor of the brain responsible for conducting impulses from one part of the body to another
The Neuron (“Nerve Cells”)
What is? Also known as soma; made up of the nucleus and cytoplasm within cell membrane
Cell body
What is? Transmits signals away from the neuron’s cell body to connect with other neurons and cells
Stem or axon
What is? Collect incoming signals from other neurons and send the signal toward the neuron’s cell body
Dendrites
What is? Composed of two separate, interconnected divisions. What are they called?
Nervous system: Central Nervous system and Peripheral nervous system
What is? Composed of the spinal cord and the brain
Central Nervous system
What is? Composed of the peripheral nerves that connect the CNS to receptors, muscles, and glands. Includes the cranial nerves just outside the brain stem. Comprises the somatic nervous system and the autonomic nervous system.
Peripheral nervous system
What is? Conveys information from the CNS to skeletal muscles; responsible for voluntary movement
Somatic nervous system
What is? Regulates internal body functions to maintain homeostasis; conveys information form the CNS to smooth muscles, cardiac muscle, and glands; responsible for involuntary movement.
Autonomic nervous system
What is? Divided into the sympathetic nervous system and the parasympathetic nervous system.
Autonomic nervous system
What is? The excitatory division ; prepares the body for stress (fight or flight); stimulates or increases activity of organs
Sympathetic nervous system
What is? Maintains or restores energy; inhibits or decreases activity of organs.
Parasympathetic nervous system
What is? Either categorized as white or gray matter?
Brain tissue
What is? composed of nerve cell bodies and dendrites; it is the working area of the brain and contains the synapses, the area of neuronal connection
Gray matter
What is? the myelinated axons of neurons
White matter
What is? Structured to contain grooves and dips of corrugated wrinkles within the brain tissue that provide anatomic landmarks or reference points.
Outermost surface of the brain
What is? Small shallow grooves in the outermost surface of the brain
Sulci
What is? Deeper groves extending into the brain
Fissures
What is? The raised tissue areas of the outermost surface of the brain
Gyri
What is? The brain subdivided into
Cerebrum and the brainstem
What is? The largest part of the brain, which is divided into two halves, the right and left hemispheres.
Cerebrum
What is? This hemisphere of the cerebrum is dominant in most people
Left hemisphere
What is? This hemisphere of the cerebrum controls the left sided body functions
Right hemisphere
What is? Both hemispheres connected by a large bundle of white matter, an area of sensorimotor information exchange between the two hemispheres
Corpus callosum
Each hemisphere of the cerebrum is divided into how many lobes?
four
What is? Largest and most developed lobe of the cerebrum
frontal lobe
What is? Frontal lobe location that is Responsible for controlling voluntary motor activity of specific muscles
motor function
What is? Frontal lobe location that Coordinates movement of multiple muscles
premotor area
What is? Frontal lobe location that Allows for multimodel sensory input to trigger memory and lead to decision-making
Association cortex
What is? Frontal lobe location of Working memory, reasoning, planning, prioritizing, sequencing behavior, insight, flexibility, judgment, impulse control, behavioral cueing, intelligence, abstraction
Seat of executive functions
What is? Frontal lobe location for Expressive speech
Language (broca’s area)
What is? Frontal lobe location of the most focal area for personality development
Personality variables
What is? Problems in this lobe of the cerebrum can lead to personality changes, emotional, and intellectual changes
Frontal lobe
What is? Blank Lobe, functions include:Language (Wernicke’s area): Receptive speech or language comprehensionPrimary auditory areaMemoryEmotionIntegration of vision with sensory informationProblems in this lobe can lead to visual or auditory hallucinations, aphasia, and amnesia
Temporal lobe
What is? Blank lobe, functions include:Primary visual cortexIntegration area: Integrates vision with other sensory informationProblems in this lobe can lead to visual field defects, blindness, and visual hallucinations
Occipital lobe
What is? Blank lobe, functions include:Primary sensory areatasteReading and writingProblems in this lobe can lead to sensory-perceptual disturbances and agnosia
Parietal lobe
What is? This brain area includes the cerebral cortex, limbic system, thalamus, hypothalamus, and basal ganglia
Cerebrum
What is? Controls wide array of behaviorsControls the contralateral side of the body Sensory information is relayed from the thalamus and then processed and integrated in the cortexResponsible for much of the behavior that makes us human: speech, cognition, judgement, perception, and motor function
Cerebral cortex
What is? Essential system for the regulation and modulation of emotions and memoryComposed of the hypothalamus, thalamus, hippocampus, and the amygdala
Limbic system
What is? Plays key roles in various regulatory functions such as appetite, sensations of hunger and thirst, water balance, circadian rhythms, body temperature, libido, and hormonal regulation
Hypothalamus
What is? Sensory relay station except for smell; modulates flow of sensory information to prevent overwhelming the cortex; regulates emotions, memory, and related affective behaviors
Thalamus
What is? Regulates memory and converts short term memory into long term memory
Hippocampus
What is? Responsible for mediating mood, fear, emotion, and aggression; also responsible for connecting sensory smell information with emotions
Amygdala
What is? Also known as the corpus striatumServes as a complex feedback system to modulate and stabilize somatic motor activity (information conveyed from the CNS to skeletal muscles)Plays a role in movement initiation; complex motor functions with association connectionsFunctions in learning and automatic actions such as walking or driving a car
Basal ganglia
What is? Contains extrapyramidal motor system or nerve tractFunctions in involuntary motor activity (e.g., muscle tone, posture, coordination of muscle movement and common reflexes)Many psychotropic medications can affect the extrapyramidal motor nerve track, causing involuntary movement side effectsContains both the caudate and the putamenProblems in this brain area can lead to bradykinesia, hyperkinesia, and dystonia.
Basal ganglia
What is? Made up of cells that produce neurotransmittersIncludes the midbrain, pons, medulla, cerebellum, and reticular formation
Brainstem
What is? Houses the ventral tegmental area and the substantia nigra (areas of dopamine synthesis)
Midbrain
What is? Houses the locus ceruleus (area of norepinephrine synthesis)
Pons
What is? Together with the pons, contains autonomic control centers that regulate internal body functions
Medulla
What is? Responsible for maintaining equilibrium; acts as a gross movement control center (e.g. control movement, balance, posture)
Cerebellum
What is? Each hemisphere of this has ipsolateral control (same side of body)Problems with this can lead to ataxia (uncoordinated and inaccurate movements).Romberg test is important for detecting deficiencies in cerebellar functioning.
Cerebellum
What is? The primitive brainInnervates thalamus, hypothalamus, and cortexRegulation functions include: Involuntary movement, reflex, muscle tone, vital sign control, blood pressure, respiratory rate, critical to consciousness and ability to mentally focus, to be alert and pay attention to environmental stimuli
Reticular formation system
What are the two classes of cells in the nervous system?
Glia and neurons
What is? Structures that form the myelin sheath around axons and provide protection and support
Gila
What is? Nerve cells responsible for conducting impulses from on part of the body to another
Neurons
Components of this include:Cell bodyDendritesAxons
Neuron
What is? Also known as soma; made up of the nucleus and cytoplasm within the cell membrane
Cell body
What is? Receives information to conduct impulse toward the cell body
Dendrites
Sends or conducts information away from the cell body
Axon
What is? The connection site and area of communication between neurons where neurotransmitters are released
Synapse or synaptic cleft
The spirit of motivational interviewing is characterized by what?
Acceptance, partnership,evocation, compassion
The four processes of motivational interviewing are?
Engage, focus, evoked, plan
The enhanced national standards for culturally and linguisticallyappropriate services and health and healthcare from the office of minority health at the US Department of Health and Human Services are composed of 15 standards that provide individuals and organizations with the blueprint for successively implementing and maintaining culturally and linguisticallyappropriate services. Culturally and linguistically appropriate healthcare and services, broadly defined his care and services that are respectful of and responsive to the cultural and linguistic needs of all individuals, are increasingly seen as essential to reducing disparities and improving healthcare quality
C LAS standards
The purpose of this is to provide a blueprint for health and healthcare organizations to implement culturally and linguistically appropriate services that will advance health equity, improve quality, and help eliminate healthcare disparities
C LAS purpose
Standard one: provide effective, equitable, understandable, and respectful quality care and services.standard two: advance and sustain governance and leadership that promotes C LAS and health equity.Standard three: recruit, promote, and support a diverse governance, leadership, and workforce.Standard four: educate and train governance, leadership, and workforce and see LAS.Standard five: offer communication and language assistance.
CLA standards
Standard six: inform individuals of the availability of language assistance.Standard seven: ensure the competence of individuals providing language assistance.Standard eight provide easy to understand materials and signage.Standard nine: infuse CLA’s goals, policies, and management accountabilities out the organizations planning and operations.Standard 10: conduct organizational assessments.Standard 11: collect and maintain demographic data.Standard 12: conduct assessments of community health assets and needs.Standard 13 partner with the community.Standard 14: create conflict and grievance resolution processes.Standard 15: communicate the organization’s progress in implementing and sustaining
C LAS standards
The synapse converts an electrical signal blank from the presynaptic neuron into a chemical signal blank that is transferred to the postsynaptic neuron
Action potential and neuron transmitter
Blank is released at the synaptic cleft as a result of electrical activity known as action potential
Neurotransmitters
The two phases of an action potential are?
Depolarization and repolarization
What is the initial phase of the action potential (an excitatory response)when sodium and calcium ions flow into the cells
Depolarization
What is the restoration phase (an inhibitory response), when potassium leaves the cell or chloride enters the cell.
Repolarization
Problem in either the structure or chemistry of this blank interrupts normal flow of impulses and stimuli, which then contribute to symptoms commonly seen in psychiatric disorders.
Synapse
Chemical synthesized from dietary substrates that communicate information from one cell to another
Neurotransmitters
The neurotransmitter will be released from the blank across the synapse and then bind to a specific receptor on the blank.
Presynaptic neuron and Postsynaptic neuron
- Neurotransmitter must be present in the nerve terminal.
- Simulation of neuron must cause release of neurotransmitter in sufficient quantities to cause an action to occur at postsynaptic membrane.
- Effects of exogenous transmitter on postsynaptic membrane must be similar to those caused by stimulation of presynaptic neuron.
- A mechanism for inactivation or metabolism of the neurotransmitter must exist in the area of the synapse
- Exogenous drugs should alter the dose, response curve of the neurotransmitter in a manner similar to the naturally occurring synaptic potential.
Classification requirements for neurotransmitters
Monoamines, amino acids, cholinergics, neuropeptides
Categories of neurotransmitters
Dopamine, norepinephrine, epinephrine, serotonin all belong to the class of this neurotransmitter
Monoamines
Known as a catecholamine; produced in the substantia nigra and the ventral tegmental area; precursor is tyrosine; removed from the synaptic cleft by monoamine oxidase enzymatic action
Dopamine
This monoamine is produced in these four pathways: mesocortical, mesolimibic, nigrostriatal, tuberoinfundibular
Dopamine
Also known as a catecholamine; produced in the locus ceruleus of the pons; precursor is tyrosine; removed from the synaptic cleft and retuned to storage via an active reuptake process; major neurotransmitter implicated in mood, anxiety, and concentration disorders
Norepinephrine
Also known as a catecholamine; produced by the adrenal glands; and also referred to as the adrenergic system
Epinephrine
Known as an indole; produced in the raphe nuclei of the brainstem; precursor is tryptophan; removed from the synaptic cleft and returned to storage via an active reuptake process; major neurotransmitter implicated in mood and anxiety disorders
Serotonin
Glutamate, aspartate, GABA, and glycine make up this category of neurotransmitters
Amino acids
What is the universal excitatory neurotransmitter; major neurotransmitter involved in process of kindling, which is implicated in seizure disorders and possibly bipolar disorders; balance implicated in mood disorders and schizophrenia
Glutamate
What is Another excitatory neurotransmitter; works with glutamate
Aspartate
Universal inhibitory neurotransmitter; site of action of benzodiazepines, alcohol, barbiturates and other CNS depressants
GABA
What is Another inhibitory neurotransmitter; works with GABA
Glycine
acetylcholine belongs to this category of neurotransmitters
Cholinergics
Synthesized by the basal nucleus of Meynert; precursors are acetylcoenzyme A and choline
Acetylcholine
Non-opioid type and opioid type belong to this category
Neuropeptides
This category of neurotransmitter modulates pain; decreased amount of this category of neurotransmitter is thought to cause substance abuse
Neuropeptides
Decrease acetylcholine causes?
Alzheimer’s disease and impaired memory
Increased acetylcholine causes?
Parkinsonian symptoms
Increase Dopamine causes?
Schizophrenia and psychosis
Decrease Dopamine causes?
Substance abuse, Anhedonia (inability to feel pleasure), Parkinson’s disease
Decreased norepinephrine causes?
Depression
Increase in norepinephrine causes what mental health condition?
Anxiety
Decreased serotonin causes?
Depression, obsessive-compulsive disorder, anxiety disorders, and schizophrenia
Decrease GABA causes?
Anxiety disorder
Glutamate increase causes?
Bipolar affective disorder, psychosis from escape mixed neurotoxicity or excessive pruning
Glutamate decrease causes?
Memory and learning difficulty, negative symptoms of schizophrenia
Opioid neuropeptides decreases causes?
Substance abuse
Serotonin 5-HT 1A
Regulation of sleep
Serotonin 5-HT1D
Pain perception
Serotonin 5-HT2
Mood states
Serotonin 5-HT2A
Temperature
Serotonin 5-HT3
Regulation/facilitation of aggression
Serotonin 5-HT4
Libido
Disadvantages of this lack sensitivity, cannot differentiate white matter from gray matter, cannot view structures close to the bone tissues, under estimation of brain atrophy, inability to image sagittal and Cornel views
CT
Autosomal dominant conditions may be present in more than one generation and up to what percent of offspring when one parent is affected such as Marfan syndrome
50%
Testing for presence of HLA-B 1502 allele, an inherited variant of HLA-B gene, is required by the FDA in people of blank descent prior to prescribing the anticonvulsant carbamazepine due to the risk of Stevens-Johnson syndrome and toxic epidermal necrolysis
Asian
Painful stick neck and thick tongue are indicated of of what medical term
Dystonia: is a movement disorder in which a person’s muscles contract uncontrollably can result in repetitive movements or abnormal posture
CNS dopamine and acetylcholine have a blank relationship. As dopamine receptors are antagonized by antipsychotic medications, acetylcholine levels increase, giving rise to what?
Reciprocal, extrapyramidal side effects
A positive Babinski or fanning of toes and dorsiflexion of the great toe is normal in infants up to age what
Two years
On old Olympus towering top a fin and German viewed some hops
Olfactory, Optic, Oculomotor, Trochlear, Trigeminal, Abducens, Facial, Acoustic, Glossopharyngeal, Vagus, Spinal Accessory, Hypoglossal
What cranial nerve ? Test sense of smell and ensure patency of the nasal passages, have the client close eyes and test each nostril separately while others is occluded, asking the client to identify familiar odors
Olfactory
What cranial nerve? Test vision using Snellen chart or other suitable chart depending on the client’s acuity and ability to cooperate. Examine the inner aspect of the eyes with the ophthalmoscope. Test peripheral vision using the confrontation test.
Optic
What cranial nerve? This is the motor nerve to the five extrinsic eye muscles. Test together with cranial nerve for an cranial nerve six. Test the extraocular movements. Check the equality of pupils, the reaction to light, and their ability to accommodate. Test the corneal light reflex, when shining a light at the bridge of the nose, the light should appear symmetrical in both eyes.
Oculomotor
What cranial nerve? Use the same processes cranial nerve three and cranial nerve six.
Trochlear
What cranial nerve? Palpate the messenger muscles with the fingertips while the client clenches his or her teeth. Look for disparity and tension between the two muscles, which can indicate paralysis on the weak side. Look for tremor of the lips, involuntary chewing movements, and spasm of the masticatory muscles.
Trigeminal motor division
What cranial nerve? Test tactical perception of the facial skin by touching with a wisp of cotton. Test superficial pain of the skin and mucosa with pinpricks. Test the sense of touch in the oral mucosa.
Trigeminal sensory division
What cranial nerve? Use the same processes for cranial nerve three and four.
Abducens
What cranial nerve? Inspect the face in repose for evidence of flaccid paralysis. Test by asking the client to elevate eyebrows, wrinkled forehead, close eyes, frown, smile, and puffed cheeks.
Facial motor division
What cranial nerve? Test taste for sugar, vinegar, and salt
Facial sensory division
What cranial nerve? Check hearing with the audiometer or by the whisper test. Check for hearing loss using the Weber and the Rinne tests.
Acoustic
What cranial nerve? Test together with cranial nerve 10
Glossopharyngeal
What cranial nerve? Tester elevation of the uvula by having the client open his or her mouth and say “ah”. Test the gag reflex by touching the back of the throat with the tongue blade.
Vagus
What cranial nerve? Test the strength of the sternocleidomastoid and trapezius muscles against resistance of your hands.
Accessory spinal
What cranial nerve? Look for tremors and other involuntary movement when the client protrudes his or her tongue.
Hypoglossal
Have the client stand up straight with feet together, arms by sides, and eyes closed. Only slight swaying would be normal, and the client will be able to sustain this post for approximately five seconds. More than slight swing suggests cerebellar ataxia or vestibular dysfunction
Equilibrium by administering the Romberg test
Ability to perform rapid alternating movements such as patting knees alternating palm and back of hands, touching thumb to each finger. The client should be able to smoothly execute these movements and maintain the rhythm.
Diadochokinesia
Inability to discriminate between objects based on touch alone; results of a lesion in the parietal lobe
Astereognsosis
Movement disorder in which a person’s muscles contract uncontrollably. Contraction causes the affected body part the twist involuntary, resulting in repetitive movements or abnormal postures.
Dystonia
Repetitive and rapid, jerky, involuntary movement that appears to be well coordinated; often seen in Huntington’s disease
Choreiform
Inability to recognize letters or numbers drawn on the clients hand with a pointed object
Agraphesthesia
Is movement disorder characterized by subjective feeling of inner restlessness accompanied by mental distress and an inability to sit still.
Akathisia
Greater than blank percentile for body mass index places the child at increased risk for being overweight
85th
The client is presenting with elevated temperature and also is taking psychotropic meds such as Tegretol or clozaril be alert for what
Agranulocytosis
What antipsychotic can cause cataracts
Quetiapine (Seroquel)
Is a milky nipple discharge unrelated to the normal milk production of breast-feeding.
Galactorrhea
Be aware that lithium and anorexia nervosa can cause what
Peripheral edema
Function of what gland is to take iodine from the circulating blood, combine it with amino acid tyrosine, and convert it to the thyroid hormones’ T3 and T4
Thyroid
The thyroid gland also stores T3 and T4 until they are released into the bloodstream under the influence of thyroid stimulating hormone released from what gland?
Pituitary
When T4 and T3 are high, TSH secretion does what?
TSH secretion decreases
When T4 and T3 levels are low, TSH secretion does what?
TSH secretion increases
This cation for the structure of bones and teeth is mediated by interactions among three hormones’: parathyroid, hormone, vitamin D, and calcitonin
CA
Confusion, decreased libido, importance, decreased appetite, memory loss, lethargy, constipation, headaches, slow or clumsy movements, syncope, weight gain, fluid retention, muscle aching and stiffness, slowed reflexes, somatic discomfort, slowed speech and thinking, sensory disturbances, cerebellar ataxia, loss of amplitude and ECG, mimics symptoms of unipolar mood disorders
Systemic effects of hypothyroidism
Mimics symptoms of bipolar affective disorder, motor restlessness, emotional lability, short attention span, compulsive movement, fatigue, tremor, insomnia, importance, weight loss, increase in appetite, abdominal pain, excessive sweating, flushing, elevated upper eyelid leading to decreased blinking, staring, fine tremor of eyelid, tachycardia, dysrhythmias
Systemic effects of hyperthyroidism
Calcium normal values
8.8 to 10.5mg/dl
Free T4 normal values
0.8 to 2.8ng/dl
Normal thyroid stimulating hormone
2 to 10 mU/l
Increased levels of what can cause: acidosis, hyperparathyroidism, cancers, vitamin D intoxication, Addison’s disease, and hyperthyroidism
Calcium
Decreased levels of what can cause alkalosis, hyperparathyroidism, renal failure, pancreatitis
Calcium
Systemic effects of what causes: increase in neuromuscular excitability, confusion, Paris thesis around the mouth and in the digits, muscle spasms in the hands and feet, hyperreflexia, convulsions, tetany, continuous severe muscle spasm, prolonged QT interval, intestinal cramping, and hyperactive bowel sounds
Hypocalcemia less then 8.5
Systemic effects of what causes: fatigue, weakness, lethargy, anorexia, nausea, constipation, behavioral changes, impaired renal function, shortened QT interval, depressed T waves, bradycardia, and heart block
Hypercalcemia Greater then 12
Normal sodium values
135 to 148mEq/l
Increased levels of what can cause: hypovolemia, dehydration, diabetes insipidus, excessive salt ingestion, gastroenteritis
Increase levels of sodium
Decreased levels of what can cause: Addison’s disease, renal disorder, G.I. fluid loss from vomiting, diarrhea, nasogastric suction, alias, diuresis
Decreased levels of sodium
Systemic effects of what causes: lethargic, headache, confusion, apprehension, seizures, coma, hypotension, tachycardia, decreased urine output, weight gain, edema, ascites, jugular vein distention.
Hyponatremia less than 135mEq/l
Systemic effects of what causes: convulsions, pulmonary edema, thirst, fever, dry mucous membranes, hypertension, tachycardia, low jugular venous pressure, restlessness
Hypernatremia greater than 147mEq/l
Normal values for magnesium
1.3 at the 2.1mEq/l
Increase levels of what can cause: Addison’s disease, adrenalectomy, renal failure, diabetic ketoacidosis, dehydration, hypothyroidism, hyperthyroidism
Magnesium
Decreased levels of what can cause: hyperaldosteronism, hypokalemia, diabetic ketoacidosis, malnutrition, alcoholism, acute pancreatitis, GA loss from vomiting, diarrhea, nasogastric suction, and for Sheila, malabsorption syndrome, pregnancy induced hypertension.
Magnesium
Systemic effects of what causes: depression, confusion, irritability, increased reflexes, muscle weakness, ataxia, nystagmus, tetany, convulsions
Hypomagnesemia less then 1.5
Systemic effects of what causes: nausea and vomiting, muscle weakness, hypertension, bradycardia, respiratory depression, depressed skeletal muscle contraction, and depressed nerve function
Hypermagnesemia greater than 2.5mEq/l
Normal chloride values
98 to 106mEq/L
Increased levels are caused by: acidosis, hyperkalemia, hyponatremia, dehydration, renal failure, Cushing’s syndrome, hyperventilation, and anemia
Chloride
Decreased levels are caused by: alkalosis, hypokalemia, hyponatremia, G.I. loss from vomiting, diarrhea, nasogastric suction, and fistula, diuresis, over hydration, Addison’s disease, burns
Chloride
Potassium normal value range
3.5 to 5.1 mEq/l
Increased levels are caused by: acidosis, insulin deficiency, Addison’s disease, acute renal failure, hypoaldosteronism, infection, dehydration
Potassium
Decreased levels are caused by: alkalosis excessive insulin, G.I. loss, laxative abuse, burns, trauma, surgery, Cushing’s syndrome, Hyperaldosteronism, thyrotoxicosis, anorexia nervosa, diet deficient in meat and vegetables
Potassium
Systemic effects of what causes: muscle weakness, paralysis, tingling of lips and fingers, restlessness, intestinal cramping, diarrhea, narrow and taller T waves, shorten QT interval, depressed ST segment, prolonged PR interval, widened QRS complex leading to cardiac arrest.
Hyperkalemia greater than 5.5mEq/l
Systemic effects of what causes: impaired carbohydrate metabolism, impaired renal function, polyurea, polydipsia, skeletal muscle weakness, and smooth muscle atony, cardiac dysrhythmias, paralysis, and respiratory arrest
Hypokalemia levels less than 3.5mEq/l
Normal values of ALT
5 to 35 U/I
Normal values of AST
5 to 40 U/I, AST has less in skeletal muscles, kidneys, pancreas, brain
GGT normal values
10 to 38 IU/I
How many stages in girls breast development
Stage one prepubertal
stage II breast Bud stage with elevation of breast and papillary; enlargement of areola
stage III further enlargement of breast and aerial; no separation of their contour
stage IV Areola and papilla form a secondary mound above level of breast
stage V mature stage projection of papilla only related to recession of a areola
How many stages in boys development of external genitalia
Stage I prepubertal
stage II enlargement of scrotum and testes; scrotum skin reddens and changes and texture
stage III enlargement of penis; further growth of testes
stage IV increase in size of penis with growth and breadth and development of glans; testes and scrotum larger, scrotum skin darker
stage V adult genitalia
How many stages and Boys and Girls Club care
Stage I prepubertal
stage II sparse growth of long, slightly pigmented hair, straight or curled, at base of penis or long labia
stage III darker, coarser, and curly hair, spreading sparsely or junction a few
stage IV adult type pair, but covering smaller area than an adult, no spread to medial surface of thighs
stage V adult type and quantity with horizontal distribution
Plan an exercise routine that last at least blank minutes, and perform the work out at least blank to blank days a week.
30 minutes, 3 to 5 days
The target heart rate during physical activity should be blank to blank of the maximum heart rate
60 the 90%
Physical activity at blank to blank of the maximum heart rate is considered moderate intensity exercise
60 to 70%
CDC recommends blank minutes or more of physical activity each day for children and adolescents
60 minutes
CDC recommends blank minutes of moderate intensity aerobic activity every week and muscle strengthening activities blank or more days a week for adults
Hundred and 50 minutes and two
All SSRIs and some other antidepressants have been implicated in blank. Owing to diminished renal function and frequent polypharmacy, blank is more common in the elderly. Water pills could make it worse.
Hyponatremia
In this condition clients can show up feeling tired, foggy, severe headache owing to cerebral edema
Hyponatremia
What client teaching should be included in preparation for beginning lithium?
The client should be taught about the potential risks and benefits of taking lithium. Women of childbearing age should be educated about the risk of birth defects, including Ebstein’s anomaly. Consideration of lithium dose and maintenance blood level should be included in discussing the relative risk. The client should be taught about the signs and symptoms of lithium toxicity.
What test should be ordered before starting lithium
Baseline labs consisting of a metabolic panel, TSH, and CBC women of childbearing age should have a pregnancy test.
In the elderly what additional test should be ordered before treating with lithium?
Those with heart disease are over the age of 65 should first have a baseline ECG
Patient started on lithium to follow up with the fire G, constipation, and bradycardia what should the provider consider his etiology?
Hypothyroidism or hypercalcemia both of which can because by lithium
What is time needed to clear 50% of the drug from the plasma
Half-life
What is the point at which the amount of drug eliminated between doses is approximately equal to the dose administered
Steady state
It takes how many half-lives to achieve a steady state and how many half-lives to completely eliminate a drug
Five
Approximately 10% of Caucasians are poor metabolizers of this P4 50 enzyme
2 D6 enzyme
Approximately 20% of Asians may have reduced activity of this P4 50 enzyme
2C 19 enzyme
First pass metabolism increase activity of P4 50 enzymes on 2C9, 2C19, 2D6, and 3A4 are common in what age group
Young children
The P4 50 enzyme1A2 pathway is delayed in what age group
Young children
Enzyme inducers can what to the serum level of other drugs that are substrates of that enzyme, thus possibly causing sub therapeutic drug levels
Decrease
Inhibitors or inducers? Bupropion, Clomipramine
Inhibitors
Inhibitors or inducers? Cimetidine and Clairthromycin
Inhibitor
Inhibitors or inducers? Fluoroquinolones and Grapefruit
Inhibitors
Inhibitors or inducers? Ketoconazole and Nefazodon
Inhibitors
Inhibitors or inducers? SSRIs
Inhibitors
Inhibitors or inducers? Carbamazepine
Inducer
Inhibitors or inducers? Hypericum (St. John’s Wort)
Inducer
Inhibitors or inducers? Phenytoin
Inducers
Inhibitors or inducers? Phenobarbital and tobacco
Inducers
Enzyme inhibitors can do what to the serum level of other drugs that are substrates of that enzyme, thus possibly causing toxic levels
Increase
Liver disease will affect liver enzyme activity and first pass metabolism, possibly resulting in what plasma drug levels
Toxic
Kidney disease or drugs that reduce renal clearance, such as NSAIDs, may what to serum concentration of drugs that are excreted by the kidneys such as lithium. Older adults are more sensitive to psychotropics because of their decreased intracellular water, protein binding, low muscle mass, decreased metabolism, and increased body fat concentration.
Increase
Most psychotropics are highly protein bound and older adults have more body fat and less protein they are more likely to develop what as a result of taking medications
Toxicity
What effect? Drug binds to receptors and activates a biological response
Agonist affect
What effect? Drug causes the opposite effect of agonist; binds to same receptor
Inverse agonist affect
What effect? Drug does not fully activate the receptors
Partial agonists affect
What effect? Drug binds to the receptor but does not activate a biological response
Antagonist affect
What kind of response? Depolarization; involves the opening of sodium and calcium channels so these ions go into the cell
Excitatory response
What kind of response? Repolarization; involves the opening of chloride channel so chloride goes into the cell, potassium leaves, or both
Inhibitory response
Another site for drug actions are enzymes, which are important for drug metabolism and play an important role in the chemical alteration of the drug. Some drugs such as what inhibit the actions of a particular enzyme, thus increasing the availability of the neurotransmitter.
MAOIs monoamine oxidase inhibitors
Another site for drug action is carrier proteins or reuptake pumps, which transport neurotransmitters out of the synapse and back into the presynaptic neuron to be recycled or reused. Some drugs, such as what, will inhibit reuptake pumps, thus increasing the synaptic availability of the neurotransmitter
SSRIs
What is the relative dose required to achieve certain effects?
Potency
What is the relative measure of the toxicity or safety of a drug; ratio of the median toxic dose to the median effective dose
Therapeutic index
Drugs with what kind of therapeutic index have a high margin of safety; that is, the therapeutic dose and the toxic dose are far apart.
High therapeutic index
Have a low margin of safety; that is, the therapeutic dose and toxic dose are close together.
Low therapeutic index
What is the process of becoming less responsive to particular drug over time
Tolerance
An acute decrease in the therapeutic response
tachyphylaxis
What schedule of medication? I abuse potential, used for research purposes only, not legally available by prescription, examples include heroin and marijuana
Schedule one
What schedule of medication? Medicinal drugs in current use, high potential for abuse and dependency, written prescription only, no telephone orders allowed, no refills allowed on prescriptions examples include morphine, codeine, methadone Dilaudid oxycodone hydrocodone amphetamine salts, methylphenidate
Scheduled two
What schedule of medications? Medicinal drugs with less abuse potential than schedule two drugs, still greater potential for abuse and schedule for drugs, telephone orders if followed by written prescription, prescription must be renewed every six months, refills limited to five, examples include testosterone, Suboxone, appetite suppressant’s
Schedule three
What scheduled medications? Medicinal drugs with less abuse potential than schedule three drugs. Examples include benzodiazepines
Schedule four
What scheduled medications? Medicinal drugs with the lowest abuse potential includes buprenorphine, codeine, Phenergan and, the Lomotil
Schedule five
Beta blockers, steroids, interferon, accutane, retroviral drugs, antineoplastic, benzodiazepines, and progesterone can induce what medical conditions?
Depression
Steroids, Antabuse, INH, and antidepressants in persons with bipolar disorder can induce what medical condition?
Mania
These drugs can cause a false positive for what: stimulants, Wellbutrin, Prozac, trazodone, ranitidine, nefazodone, nasal decongestants, pseudoephedrine
Amphetamines
This drug can cause a false positive for what: valium
Alcohol