NT and Their Receptors

Question 1

Function of
1. Mesocortical
2. Mesolimbic
3. Nigrostriatal
4. Tubuloinfundibular
pathway

Answer 1

1. Cognition and executive function, regulation of emotion and affect
2. Regulation of emotional behaviours, including motivation, incentive, salience and reward
3. To basal ganglia, control of cortical output
4. Controls PRL secretion

Question 2

Side effects caused by
1. 5HT2
2. 5HT3
receptors

Answer 2

1. Jitteriness, insomnia, sexual dysfunction

2. Nausea, headache

Question 3

Positive symptoms of schizophrenia

Answer 3

Hallucinations
Delusions
Disorganization (behaviour and speech - tangentiality, circumstantiality, derailment, neologisms, word salad)

Question 4

Negative symptoms of schizophrenia

Answer 4

Decreased expressiveness
Apathy
Flat affect
Lack of energy

Question 5

Cognitive deficits in schizoprenia

Answer 5

Processing speed
Attention
Working memory
Verbal/visual learning and memory
Reasoning/executive functioning
Verbal comprehension
Social cognition