NSG 219- Pharmacology Flashcards
What is pharmacokinetics? What is ADME?
How medications travel throughout the body. Absorption, Distribution, Metabolism Excretion
What is absorption?
Transmission of med from site of administration
What are the most common routes for absorption?
Eternal and parenteral
What determines intensity of a medication effect?
The amount absorbed
What determines how soon medication takes effect?
The rate
What effects the rate and amount of absorption?
Route
What is distribution?
The transport of meds throughout the body
What factors influence the distribution of meds?
Circulation, permeability of membrane and plasma protein binding
What is metabolism? Where does it happen?
How quickly a med is processed. Happens usually in the liver, but can happen in the lungs, kidney and blood vessels
What factors effect metabolism?
Age, nutritional status, first pass effect, similar metabolic pathway
What is excretion? How is this done?
Eliminating a med from the body. Done by the kidneys
What labs must be monitored?
BUN and Creatinine
Oral Meds: Barrier to absorption and Absorption pattern
Barrier to Absorption: Cells of GI. Absorption Pattern: Varies based on many factors
Sublingual Meds: Barrier to absorption and Absorption pattern
Barrier to absorption: Swallowing before dissolved. Absorption pattern: Quick
Other Mucous membrane Meds: Barrier to absorption and Absorption pattern
Barrier to absorption: stool, or tissue. Absorption pattern: easy
Inhalation Meds: Barrier to absorption and Absorption pattern
Barrier to Absorption: Inspiratory effect. Absorption pattern: Rapid
Intradermal or Topical Meds: Barrier to absorption and Absorption pattern
Barrier to absorption: Cells. Absorption pattern: slow
SubQ and IM Meds: Barrier to absorption and Absorption pattern
No barrier and rapid absorption
IV Meds: Barrier to absorption and Absorption pattern
No barrier and immediate absorption
What is Half-life?
Time it takes for the amount of med to decrease by 50% in the body
Short half-life
Med leaves body quickly (4-8 hours)
Long half life
Med stays in body longer (24+ hours)