NSAIDs Table Flashcards
List the traditional NSAIDs. (6)
Ibuprofen Naproxen Ketorolac Diclofenac Indomethacin Meloxicam
Mechanism of action of traditional NSAIDs?
Reversible inhibition of COX-1 AND COX-2
Where are each of the traditional NSAIDs metabolized?
Ibuprofen - hepatic Naproxen - Renal Ketorolac - renal Diclofenac - hepatic Indomethacin - hepatic Meloxicam - hepatic
What symptoms are traditional NSAIDs used to treat?
Pain, fever, and inflammation
What is more effective for acute pain relief, acetaminophen or tNSAIDs?
tNSAIDs
What traditional NSAID causes GI toxicity, which limits its use to 5 days?
Ketorolac
What traditional NSAID comes with the greatest increase in risk for MI and stroke?
Diclofenac
List some adverse reactions to traditional NSAIDs.
Bleeding, GI upset, renal dysfunction (fluid retention causing increase in BP), GI toxicity causing ulcers
What property of acetaminophen causes it not to have anti inflammatory properties?
It works on COX-2 only in CNS, not periphery.
Name 1 COX-2 selective NSAID.
Celecoxib
How does celecoxib compare to tNSAIDs in terms of pain reduction?
Less effective in pain reduction that tNSAIDs
How does celecoxib compare to tNSAIDs in terms of anti-inflammation?
Equal
Adverse effects of celecoxib?
Renal dysfunction, delayed labor, close ductus arteriosus, prothrombotic potential.
Acetaminophen dosing should be limited to less than ___ per day due to concerns of ____.
4g
Hepatotoxicity
Treatment for hepatotoxicity due to acetaminophen overdose?
N-acetylcysteine
