NSAIDs - General Flashcards
What is the father of steroidal anti-inflammatory drugs (SAIDs)?
Prednisone
How are NSAIDs classified?
Most are characterized by a specific family denoted by the drugs’ chemical structure.
What is most commonly true when comparing the potency of one NSAID to another?
No one NSAID is more potent than another.
What chemical is the precursor to inflammatory mediators discussed in this section and what pathway leads to each inflammatory mediator?
Arachadonic Acid (AA)
AA –> COX-1 and CPX-2 –> Prostaglandins
AA –> LO enzyme –> Leukotrienes and Bradykinin
What is the mechanism of action of NSAIDs?
Blocks COX-1 and COX-2 pathways inhibiting production of prostaglandins.
What is the mechanism of action of leukotriene receptor antagonists?
Prevent inflammation by preventing leukotrienes from binding to their receptors.
What is the mechanism of action of steroids with regard to inhibiting inflammation?
Inhibit formation of arachadonic acid thereby inhibiting production of prostaglandins and leukotrienes.
Describe the pathophysiology of an “allergy” to NSAIDs.
Some people make excess leukotrienes and bradykinin in response to NSAIDs. Overproduction of bradykinin induces angioedema.
What two medications most commonly induce angioedema?
NSAIDs and ACEIs
What do all proponic acid NSAIDs have in their name and list some examples?
“pro” –> Femoprofen, flurbiprofen, ibuprofen
List 5 indications for the administration of NSAIDs.
Arthritic diseases (osteo, rheumatoid, etc.), gouty arthritis, headache, pain, chemotherapy (maybe)
What are the “three As” of NSAIDs’ mechanism of action?
Anti-inflammatory
Antipyretic
Analgesic
T/F Excessive NSAID use can cause hypothermia.
F - NSAIDs never reduce temperature below normal
What is the primary inflammatory mediator associated with pain?
Prostaglandins.
What is true about the ability of different NSAIDs to inhibit COX-1 and COX-2 activity?
Different NSAIDs will inhibit COX-1 and COX-2 in differing grades.