NSAIDs

Question 1

Ibuprofen is what brand name medication?

Answer 1

Advil, motrin

Question 2

Naproxen is what brand name medication

Answer 2

Naprosyn (Rx), Aleve (OtC)

Question 3

Acular, Acular LS, and Acuvail are what generic Opthalmic NSAID?

Answer 3

Ketorolac Tromethamine

Question 4

Ilevro (susp) and Nevanac (sus) are what generic opthalmic NSAID?

Answer 4

Nepafenac

Question 5

Bromdac and Prolensa are what generic opthalmic NSAID

Answer 5

Bromfenac

Question 6

Ocufen is what generic opthalmic NSAID

Answer 6

Flurbiprofen sodium

Question 7

What is the MOA of NSAIDS?

Answer 7

prostaglandin inhibitor via inhibition of the cyclooxygenase enzyme

Question 8

What are the 3 functions of prostaglandins?

Answer 8

Support Renal and Platelet function, Protect gastric mucosa, inflammation and pain

Question 9

What cascade do NSAIDs effect?

Answer 9

Arachidonic Acid Cascade

Question 10

What are the 2 cyclooxgenase enzymes?

Answer 10

Cox-1 and Cox-2

Question 11

Which Cox enzyme is the main one circulating around the system?

Answer 11

Cox-1

Question 12

Which Cox enzyme is the one induced after injury?

Answer 12

Cox-2

Question 13

Cox-_ inhibition causes all the issues with NSAIDs

Answer 13

Cox-1

Question 14

Anti-Pyretic = ?

Answer 14

decreases fever

Question 15

Analgesics = ?

Answer 15

decrease pain

Question 16

Aspirin causes _______ inhibition of platelets.

Answer 16

irreversible

Question 17

NSAIDs cause ______ inhibition of platelets

Answer 17

reversible

Question 18

NSAIDs _____ risk of cardiac events

Answer 18

increase

Question 19

COX-2 inhibitors only decrease ______?

Answer 19

GI toxicity

Question 20

Celecoxib (Celebrex) is a COX-2 ____ inhibitor

Answer 20

specific

Question 21

Meloxicam (Mobic) is a COX-2 _____ inhibitor

Answer 21

selective

Question 22

What is the only IV NSAID available? What is the maximum # of days it can be used?

Answer 22

Ketoralac. max of 5 days.

Longer increases risk of renal effects and bleeding

Question 23

At what mg/day must a pt take to see NSAID anti-inflammatory mechanism?

Answer 23

1200 mg/day

Question 24

When should a pt discontinue using aspirin prior to surgery?

Answer 24

1 week

Question 25

When should a pt discontinue NSAIDs prior to surgery?

Answer 25

3 days

Question 26

Prostaglandins are needed to maintain _____ and blood flow to the kidneys

Answer 26

Vasodilation. If inhibiting, kidneys may shut down

Question 27

The salicylate structure of ______ causes high events of tinnitius and other CNS problems

Answer 27

aspirin

Question 28

If the pt has a sulfa-allergy, may have a cross reaction with

Answer 28

Celecoxib (Celebrex)

Question 29

What is the most common CNS reaction to NSAIDs/aspirin?

Answer 29

Tinnitus (ringing in the ears)

Question 30

If aspirin is given during viral infections in children, it can cause what syndrome?

Answer 30

Reye Syndrome

Question 31

About ___% of pts treated chronically with NSAIDs will develop ulcers, bleeding, or perforation.

Answer 31

15%. Taking with food will help