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Pharm 2 > NSAIDs > Flashcards

NSAIDs Flashcards

1
Q

Ibuprofen is what brand name medication?

A

Advil, motrin

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2
Q

Naproxen is what brand name medication

A

Naprosyn (Rx), Aleve (OtC)

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3
Q

Acular, Acular LS, and Acuvail are what generic Opthalmic NSAID?

A

Ketorolac Tromethamine

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4
Q

Ilevro (susp) and Nevanac (sus) are what generic opthalmic NSAID?

A

Nepafenac

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5
Q

Bromdac and Prolensa are what generic opthalmic NSAID

A

Bromfenac

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6
Q

Ocufen is what generic opthalmic NSAID

A

Flurbiprofen sodium

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7
Q

What is the MOA of NSAIDS?

A

prostaglandin inhibitor via inhibition of the cyclooxygenase enzyme

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8
Q

What are the 3 functions of prostaglandins?

A

Support Renal and Platelet function, Protect gastric mucosa, inflammation and pain

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9
Q

What cascade do NSAIDs effect?

A

Arachidonic Acid Cascade

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10
Q

What are the 2 cyclooxgenase enzymes?

A

Cox-1 and Cox-2

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11
Q

Which Cox enzyme is the main one circulating around the system?

A

Cox-1

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12
Q

Which Cox enzyme is the one induced after injury?

A

Cox-2

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13
Q

Cox-_ inhibition causes all the issues with NSAIDs

A

Cox-1

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14
Q

Anti-Pyretic = ?

A

decreases fever

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15
Q

Analgesics = ?

A

decrease pain

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16
Q

Aspirin causes _______ inhibition of platelets.

A

irreversible

17
Q

NSAIDs cause ______ inhibition of platelets

A

reversible

18
Q

NSAIDs _____ risk of cardiac events

A

increase

19
Q

COX-2 inhibitors only decrease ______?

A

GI toxicity

20
Q

Celecoxib (Celebrex) is a COX-2 ____ inhibitor

A

specific

21
Q

Meloxicam (Mobic) is a COX-2 _____ inhibitor

A

selective

22
Q

What is the only IV NSAID available? What is the maximum # of days it can be used?

A

Ketoralac. max of 5 days.

Longer increases risk of renal effects and bleeding

23
Q

At what mg/day must a pt take to see NSAID anti-inflammatory mechanism?

A

1200 mg/day

24
Q

When should a pt discontinue using aspirin prior to surgery?

A

1 week

25
Q

When should a pt discontinue NSAIDs prior to surgery?

A

3 days

26
Q

Prostaglandins are needed to maintain _____ and blood flow to the kidneys

A

Vasodilation. If inhibiting, kidneys may shut down

27
Q

The salicylate structure of ______ causes high events of tinnitius and other CNS problems

A

aspirin

28
Q

If the pt has a sulfa-allergy, may have a cross reaction with

A

Celecoxib (Celebrex)

29
Q

What is the most common CNS reaction to NSAIDs/aspirin?

A

Tinnitus (ringing in the ears)

30
Q

If aspirin is given during viral infections in children, it can cause what syndrome?

A

Reye Syndrome

31
Q

About ___% of pts treated chronically with NSAIDs will develop ulcers, bleeding, or perforation.

A

15%. Taking with food will help

Pharm 2 (4 decks)

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