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Pharm 2 > Anti-Lipid Medications > Flashcards

Anti-Lipid Medications Flashcards

1
Q

“Statins” work by inhibiting the enzyme responsible for _____ synthesis in the liver

A

cholesterol

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2
Q

True or False: “Statins” lower LDL, lower triglycerides, and increases HDL.

A

True

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3
Q

Atorvastin = ________ (brand name)

A

Lipitor

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4
Q

Fluvastatin = ________ (bn)

A

Lescol

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5
Q

Lovastatin = ______ (bn)

A

Mevacor

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6
Q

Pravastatin = ______ (bn)

A

pravachol

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7
Q

Simvastatin = _______ (bn)

A

Zocor

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8
Q

Rosuvastatin = ______ (bn)

A

Crestor

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9
Q

Pitavastatin = ______ (bn)

A

Livalo

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10
Q

Which statin is the most potent?

A

Rosuvastatin (crestor)

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11
Q

Which statin is the 2nd most potent?

A

Atorvastatin (Lipitor)

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12
Q

Which statin is the least potent?

A

fluvastatin (Lescol)

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13
Q

When should the patient take their anti-lipid med? Why?

A

Should take at bedtime. Cholesterol is made when we sleep.

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14
Q

Each doubling of daily dose will equalt ____% reduction in LDL. What’s this MOA called?

A

6% reduction.

Rule of 6 - most significant reduction in LDl occurs at starting dose

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15
Q

Simvastatin (Zocor) cannot be used at 80mg. Why?

A

pts were more likely to have muscle breakdown which resulted in kidney failure

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16
Q

What statin is the only agent documented to get rid of plaque in pts with heart disease?

A

Rosuvastatin (Crestor)

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17
Q

Which 2 statins are allowed to be used at high-intensity doses?

A

Rosuvastatin (Crestor) 20-40mg and Atorvastatin (Lipitor) 40-80mg

18
Q

The patient complains of muscle aches or double vision = ?

A

Myopathy - labs were not done yet

19
Q

The patient feels achey but they’re labs come back good = ?

A

Myalgia

20
Q

the patient has muscle aches and labs come back bad = ? What’s the next step?

A

Myositis, must discontinue drugs

21
Q

The patient has muscle breakdown that has flooded the kidneys, causing kidney failure = ?

A

Rhadomyolysis

22
Q

What is the most common side effect of using statins? How can it be fixed?

A

Memory loss, add good fat back into the diet (fish oil, coconut oil)

23
Q

A pt with current CV disease should use ____ intensity doses.

A

high

24
Q

If the pt is over 75 years of age with CV disease.. we should use ____intensity doses.

A

moderate

25
Q

If pt has LDL > 190 mg/dL, we should use ____ intensity doses

A

high

26
Q

Moderate-intensity doses may lower LDL by ___ to ____%

A

30 to 50%

27
Q

High-intensity doses may lower LDL equal to or more than ____%

A

50%

28
Q

Niacin = _____ brand name

A

Niaspan

29
Q

T or F: Niacin lowers LDLs and TG while increasing HDL

A

True

30
Q

What is the 2ndary drug for cholesterol issues?

A

Niacin

31
Q

What is the biggest problem with Niacin?

A

Must use large doses to see effects

32
Q

What are the side effects of using Niacin?

A

Cutaneous flushing, liver dysfunction, muscle aches

33
Q

What are the 2 fibric acid derivatives?

A

Fenofibrate (Tricor) and Fenofibric Acid (Trilipix)

34
Q

Fibric Acid Derivatives can treat ____ only.

A

TGs

35
Q

What are the side effects of fibric acid derivative?

A

gallstones and cholecystitis, muscle aches (myocitis and myopathy)

36
Q

Ezetimibe (Zetia) is a type of ______ absorption inhibitor.

A

cholesterol absorption

37
Q

Ezetimibe (Zetia) works on which ____ cholesterold only.

A

LDL

38
Q

Ezetimibe works by inhibiting ____% of small intestinal absorption of cholesterol

A

54%

39
Q

The side effects of Ezetimibe (Zetia) are?

A

GI and musculoskeletal

40
Q

What are the most beneficial components of Omega-3-fatty acids

A

EPA and DHA

Pharm 2 (4 decks)

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