Anti-Lipid Medications Flashcards
“Statins” work by inhibiting the enzyme responsible for _____ synthesis in the liver
cholesterol
True or False: “Statins” lower LDL, lower triglycerides, and increases HDL.
True
Atorvastin = ________ (brand name)
Lipitor
Fluvastatin = ________ (bn)
Lescol
Lovastatin = ______ (bn)
Mevacor
Pravastatin = ______ (bn)
pravachol
Simvastatin = _______ (bn)
Zocor
Rosuvastatin = ______ (bn)
Crestor
Pitavastatin = ______ (bn)
Livalo
Which statin is the most potent?
Rosuvastatin (crestor)
Which statin is the 2nd most potent?
Atorvastatin (Lipitor)
Which statin is the least potent?
fluvastatin (Lescol)
When should the patient take their anti-lipid med? Why?
Should take at bedtime. Cholesterol is made when we sleep.
Each doubling of daily dose will equalt ____% reduction in LDL. What’s this MOA called?
6% reduction.
Rule of 6 - most significant reduction in LDl occurs at starting dose
Simvastatin (Zocor) cannot be used at 80mg. Why?
pts were more likely to have muscle breakdown which resulted in kidney failure
What statin is the only agent documented to get rid of plaque in pts with heart disease?
Rosuvastatin (Crestor)
Which 2 statins are allowed to be used at high-intensity doses?
Rosuvastatin (Crestor) 20-40mg and Atorvastatin (Lipitor) 40-80mg
The patient complains of muscle aches or double vision = ?
Myopathy - labs were not done yet
The patient feels achey but they’re labs come back good = ?
Myalgia
the patient has muscle aches and labs come back bad = ? What’s the next step?
Myositis, must discontinue drugs
The patient has muscle breakdown that has flooded the kidneys, causing kidney failure = ?
Rhadomyolysis
What is the most common side effect of using statins? How can it be fixed?
Memory loss, add good fat back into the diet (fish oil, coconut oil)
A pt with current CV disease should use ____ intensity doses.
high
If the pt is over 75 years of age with CV disease.. we should use ____intensity doses.
moderate
