NSAIDS Flashcards
Aspirin
Irreversible nonselective COX inhibitor
Pain relief, fever, anti- inflammatory, anti-clotting
Gastric ulcer, kidney injury, sensitivity, Reyes
Sodium Salicylate
Metabolite of aspirin, weak reversible COX inhibitor
Pain relief, fever, anti- inflammatory
Gastric ulcer, kidney injury
Salsalate
Hydrolyzed in small intestine to salicylate
Chronic inflammatory like collagen vascular disease
Kidney injury
Ketorolac
IV aspirin-like drug used in place of morphine
Post-surgery pain relief
Acute GI & kidney tox: only use for 5 days
Diflusinal
Competitive inhibitor of COX
Pain relief, longer half life
Gastric ulcer, kidney injury
Ibuprofen
Reversible nonselective COX inhibitor
Osteo/rheumatoid arthritis, analgesia, dysmenorrhea, fever, patent ductus arteriosus
Gastric ulcer, kidney injury
Naproxen
Reversible nonselective COX inhibitor
Osteo/rheumatoid arthritis, analgesia, dysmenorrhea, fever, patent ductus arteriosus
Gastric ulcer, kidney injury
Sulindac
Recirculates in bile, longer lasting with less GI tox
Osteo/rheumatoid/gouty arthritis, spondylitis
Kidney injury
Indomethacin
Potent anti-inflammatory used for chronic inflamm
Rheumatoid/gouty arthritis
CNS: Headache, Depression, Psychosis
Celecoxib
COX-2 selective (less), lower GI tox, no +MI risk
Arthritis, Decrease colon polyps in FAP
Myocardial infarction in patients at risk? Kidney
Rofecoxib
COX-2 selective, lower GI tox, +MI risk
Off the market
Myocardial infarction in patients at risk. Kidney
Mesalamine
Poor systemic absorption, concentrates in gut
Inflammatory bowel disease
Headache, diarrhea
Sulfasalazine
Converted to mesalamine by colonic bacteria
Inflammatory bowel disease
Headache, nausea
Acetaminophen
Converted to a COX inhibitor (AM404) in the CNS
Pain relief, fever
Less GI, clotting effects NOT anti-inflamm
Severe liver damage in high dose (oxidative) Kidney, sensitivity rxn
N-acetylcysteine
Antidote to acetaminophen tox
Acetaminophen overdose Give within 10-36 hrs
