NSAIDs Flashcards
what drugs are Acytesalicylates?
Aspirin and Diflunisal
What drugs are proprionic acid derivatives
Ibuprofen and naproxen
What drugs are indole derivatives
Indomethacin
what drugs are oxicams
piroxicam, meloxicam, tenoxicam
COX-2 selective inhibitor
celecoxib
What are the 6 groups of NSAIDs?
Acytesalicylates, proprionic acid derivatives, indole derivatives, oxicams, COX-2 selective inhibitor, Phenyl acetic acid derivatives
What is the mechanism of action of Aspirin
inhibition of COX enzymes
low doses preferentially inhibits platelet COX1
high doses inhibit systemic COX 1 and COX2
What is the mechanism of action of Ibuprofen? What is its unique use?
an NSAID that non-selectively inhibits COX1 and COX2
other uses: Close PDA
what is the mechanism of action of Naproxen (aleve)
an NSAID that non-selectively inhibits COX1 and COX2
what are the 3 things NSAIDs do?
Anti-pyretic (fever reducer), Anti-inflammatory, Analgesics (pain reducer)
What is the mechanism of action of Indomethacin? what is it used for?
inhibits PGF2alpha- prevents uterin smooth muscle contraction, delays premature labor, more potent anti-inflammatory drug than aspirin
used to close PDA
what are the side effects of Indomethacin? What are the contraindications?
GI and CNS
contraindications= GI disease
What are the side effects of Aspirin (ASA)
GI upset
Information for Piroxicam
NSAID
used for Osteoarthritis and Rheumatoid arthritis
strong analegic effects like opiods
What is Meloxicam
an NSAID
COX2 selective inhibitor
used for RA and OA
less side effects than other NSAIDs
What are the 3 phenyl acetyl acid derivatives? what types of conditions should they be used?
Ketorlax, tolmetin, Diclofenac
chronic long term inflammatory conditions
what is the mechanism of action of Celecoxib?
COX2 selective inhibitor
NSAID
no GI side effects because no COX 1 inhibition at therapeutic level
What 2 drugs are used to close PDA
Ibuprofen and Indomethacin are used with cardiac catherization
What keeps PDA open?
PGE2 and PGI2
What is a very rare condition the NSAIDs causes
SCARS
Steven Johnsons Syndrome- life threatening skin condition where epidermis and dermis separate
due to NSAID reaction
What is associated with spontaneous aborption
non-aspirin NSAIDs
Reyes Syndrome?
rare condition of <16 yo characterized by encephalopathy and steatosis that develops from a virus infection after the NSAID use- reason why only give kids acetominophen
What are the toxicity signs of Aspirin
tinnitus, dehydration, fever, coma, metabolic acidosis, renal and respiratory failure
Misoprostol?
PGE1
prevents NSAID induced gastric ulcers
labor induction for miscarriage
Dinoprostone
PGE2
cervical ripening
Dinoprost
PGF2alpha
labor induction
Carboprost
PGF2alpha
labor induction, post partum hemorrhage
Latanoprost
PGF2alpha
glaucoma
Travoprost
PGF2alpha
glaucoma
Epoprostenol
PGI2
vasodilator, inhibit platelet aggregation
used in pulmonary hypertension
