DMARDS Flashcards
Etanercept
TNFalpha inhibitor
Fusion protein ( IgG Fc region with TNF receptor)
Embrel
Infliximab
TNFalpha inhibitor
Chimeric monoclonal antibody
Remocade
Adalimumab
TNF inhibitor
Human monoclonal antibody
Humira
Leflunomide
Inhibits Pyrimidine synthesis, DNA synthesis and proliferation of activates T and B cells
Methotrexate
Inhibits purine synthesis by inhibiting frolic acid synthesis, which causes accumulation of adenosine and inhibits T cell activation and B cell proliferation
1st line choice for autoimmune diseases
Tocilizumab
Human Monoclonal antibody against IL6 receptor
Anakinra
Human Monoclonal antibody against IL 1 receptor
Anti-malarial drugs?
Chloroquine and hydroxycholorquine
Effective against RA and lupus
Retuximab
Inhibits B cells
Monoclonal antibody against CD20
Abatacept
Fusion protein of CTLA4-IgG1 Fc region
Inhibits T cells
Interfere with costimulation and inhibits T cell activation
blocks the binding of CD80/CD86 to CD28