DMARDS Flashcards

0
Q

Etanercept

A

TNFalpha inhibitor
Fusion protein ( IgG Fc region with TNF receptor)
Embrel

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1
Q

Infliximab

A

TNFalpha inhibitor
Chimeric monoclonal antibody
Remocade

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2
Q

Adalimumab

A

TNF inhibitor
Human monoclonal antibody
Humira

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3
Q

Leflunomide

A

Inhibits Pyrimidine synthesis, DNA synthesis and proliferation of activates T and B cells

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4
Q

Methotrexate

A

Inhibits purine synthesis by inhibiting frolic acid synthesis, which causes accumulation of adenosine and inhibits T cell activation and B cell proliferation

1st line choice for autoimmune diseases

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5
Q

Tocilizumab

A

Human Monoclonal antibody against IL6 receptor

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6
Q

Anakinra

A

Human Monoclonal antibody against IL 1 receptor

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7
Q

Anti-malarial drugs?

A

Chloroquine and hydroxycholorquine

Effective against RA and lupus

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8
Q

Retuximab

A

Inhibits B cells

Monoclonal antibody against CD20

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9
Q

Abatacept

A

Fusion protein of CTLA4-IgG1 Fc region
Inhibits T cells
Interfere with costimulation and inhibits T cell activation
blocks the binding of CD80/CD86 to CD28

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