NSAIDS

Question 1

pKa 3.5
Upper GI absorption 70%

Answer 1

Aspirin

Question 2

Aminophenol
Analgesic
IV/PO/PR
10mg/ml or 500mg. 15mg/kg 4-6hrs
COX-3 inhibitor
A 80% BA PO, pka 9.5 (acid), D VD 0.9L/kg, M gluc and sulf + small amount ox to NAPQ which is detox by combo glutathione
E renally

Upper GI absorption 70-90%

Answer 2

Paracetamol