Local Anaesthetics

Question 1

Duration of action medium
Max dose (mg/kg) 3 or 7
pKa 7.9
Ionised % @ pH 7.4 75%
Protein binding % 70%
Toxic plasma levels (mcg/ml) >5

Answer 1

Lidocaine

Question 2

Duration of action Long
Max dose (mg/kg) 2
pKa 8.1
Ionised % @ pH 7.4 85
Protein binding % 95
Toxic plasma levels (mcg/ml) >1.5

Answer 2

Bupivacaine

Question 3

Duration of action medium
Max dose (mg/kg) 6
pKa 7.7
Ionised % @ pH 7.4 60-70
Protein binding % 55
Toxic plasma levels (mcg/ml) >5

Answer 3

Prilocaine

Question 4

Duration of action long
Max dose (mg/kg) 3.5
pKa 8.1
Ionised % @ pH 7.4 85
Protein binding % 94
Toxic plasma levels (mcg/ml) >4

Answer 4

Ropivacaine