Nov22 M3-Pathology - Coronary Artery Disease Flashcards

1
Q

ischemic heart disease and causes

A

imbalance of supply demand to myocardium. 90% caused by CAD. also anemia, low flow states

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2
Q

critical stenosis def + why

A

70% stenosis, no symptoms below that

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3
Q

90% stenosis problem

A

symptoms at rest

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4
Q

stable vs unstable angina

A
stable = occurs at predictable lvl of exercise
unstable = happening with less and less exertion
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5
Q

acute MI def

A

cardiomyocyte death

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6
Q

acute coronary syndrome includes what

A

unstable angina, acute MI, SCD (sudden cardiac death)

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7
Q

subendocardial vs transmural infarct causes

A

subendocardial if partially occlusive thrombus (can also give unstable angina). transmural MI if completely occlusive thrombus

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8
Q

angina phenomenon happening

A

ischemia

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9
Q

why infarct initially subendocardial and then dev to transmural

A

because receives most pressure (most compression on vessels) + furthest from coronaries. infarction progresses towards epicardium

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10
Q

subendocardial infarct starts with _______

A

incomplete stenosis

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11
Q

subendocardial vs transmural MI on ECG

A

subend: no Q wave, ST depression, T wave inversion, NSTEMI

transmural MI: STEMI. Q waves, St elevation

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12
Q

LAD stenosis consequence

A

antero-septal subendocardial MI

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13
Q

posterior descending stenosis conseq

A

postero-septal subendocardial MI

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14
Q

RCA, LAD and LCX stenosis conseq

A

circumferential subendocardial MI

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15
Q

LAD complete occlusion conseq

A

anteroseptal transmural MI

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16
Q

RCA complete occlusion conseq

A

postero-septal transmural MI

17
Q

microscope findings after infarct 1 day

A

wavy fibers, eosinophilic

18
Q

microscope findings after infarct 2-3 days

A

PMNs infiltration

19
Q

microscope findings after infarct 7-10 days

A

macrophages clean (eat dead myocyte) + neutrophils gone

20
Q

microscope findings after infarct 14 days

A

new vessels, collagen (granulation tissue)

21
Q

microscope findings after infarct 7 weeks+

A

collagen scar

22
Q

main complications of MI

A

HF, cardiogenic shock, arrhythmias, vent rupture (tamponade), mural thrombus and embolism, septum shunt, valve dysfct (if pap muscle)