Notochord and Somites Flashcards
How is the dorsal-ventral axis of the notochord established?
High Shh ventrally and BMPs dorsally
What receptor does Shh bind to?
Patched
Does Patched (Shh receptor) have constitutive activity?
Yes
How does Patched function?
Inhibits Smoothen. Inhibition of Smoothen leads to inactivation of Gli so that it cannot bind to DNA.
How does Ssh control gene expression?
It inhibits the activity of Patched so that Smoothen is actives and Gli is able to bind to DNA.
What signalling molecule is concentrated at the anterior end during brain development?
Otx2
What signalling molecule is concentrated at the spinal cord/posterior end during brain development?
Gbx2
Which signalling molecules divide the anterior part of the brain and the cerebellum?
Wnt1 (near brain) and FGF8 (near cerebellum)
What will the diencephalon form?
Thalamus
What will form the cortex?
Telencephalon
Which cells share a neural origin?
Neurons, oligodendrocytes and astrocytes.
What to areas of the brain regenerate in the brain?
Hippocampus and olfactory bulb.
Which gene is expressed at the posterior part of the brain?
Emx2
Which gene expressed in the anterior part of the brain?
Pax6
What is the function of Emx2 and Pax6?
Form the posterior and anterior parts of the brain, respectively. The two inhibit each other.
