Normocytic Anemia

Question 1

2 types of hemolytic anemia

Answer 1

Intrinsic and extrinsic

Question 2

Inherited disorders characterized by either defects in the RBC’s plasma membrane, defects in certain intracellular enzymes, or abnormal hemoglobin

Answer 2

Intrinsic hemolytic anemia

Question 3

Hemolytic anemia affects RBC in what way

Answer 3

Their elasticity or ability to protect itself from mechanical and chemical stresses as it circulates through the spleen and transverses narrow tissue capillaries

Question 4

Acquired disorders associated with some external injury to otherwise normal RBC.

Answer 4

Extrinsic hemolytic anemias

Question 5

Clinical clues that suggest hemolysis

Answer 5

1) Sudden or rapid onset of anemia (fall in hemoglobin more than 1 g/dl/day) in a patient with no evidence of bleeding
2) Jaundice
3) splengomegaly 4) hx of anemia since childhood
5) family hx 6) autoimmune disease, leukemia, lymphoma 7) use of drugs associated w/ hemoysis

Question 6

When spleen removes old RBC from circulation, heme portion is broken down into

Answer 6

Iron and bilirubin

Question 7

Bone marrow failure is AKA

Answer 7

Aplastic Anemia

Question 8

A reduction of RBC, WBC, and platelets in the bood

Answer 8

pancytopenia

Question 9

Dignosis of aplastic anemia is confirmed with

Answer 9

Bone marrow biopsy demonstrating reduced numbers of RBC, WBC, and megakaryocytes on bone marrow biopsy

Question 10

Cause of death in people with aplastic anemia

Answer 10

Infection or bleeding