Hemostasis Flashcards
Thrombin –> fibinogen –> fibrin clot
For this to occur what must be present
Plasma membrane and calcium
Factors II, VII, IX, and X are dependent on what
Vitamin K
Aspirin interferes with PTL aggregation by blocking the formation of
Thomboxane A2
Coumanin (Warfarin) produces anticoagulant effects by interfering with the ability of …
Vit K to serve as a co-factor in the synthesis of these coagulation factors (esp. Factor VII)
The overlap of the extrinsic and intrinsic pathway result in the common pathway. What steps are included in this step:
Activation of Factor X, the formation of Thrombin, and the conversion of Fibrinogen to fibrin
Key players in terminating coagulation
Antithrombin, Protein C, and Protein S
Heparin amplifies the effects of _______ a thousand fold
antithrombin
Protein C inactivates ________ and ______ to decrease the formation of thrombin
Factor V and Factor VIII
_______ is a co-factor required for the normal function of protein C
Protein S
The most important rxn in the fibrinolytic system is the formation of ______ from the plasma protein _______
1) plasmin
2) plasminogen
Lab test: Bleeding Time is measuring if what things are working?
Small wound so PLT plug alone should stop bleeding. Therefore measuring *PTL function and activity of VWF.
Normal bleeding time = <10 minutes
2 lab tests of primary hemostasis
Bleeding Time and PLT count
3 lab tests of secondary hemostasis
Prothrombin Time (PT), International Normalized Ratio (INR), and Partial Thromboplastin Time (PTT)
A procedure that measures the activity of the coagulation factors in the extrinsic and common pathways by measuring how long it takes plasma to clot in a test tube after tissue factor (rat brain) and Ca2+ has been added
Prothrombin Time (PT) Normal range: 11-13 seconds
This lab procedure is used to evaluate the activity of coagulation factors in the intrinsic and common pathways by measuring how long it takes plasma to clot in a test tube after substances such as silicate particles (Georgia clay) have been added to the plasma
Partial Thromboplastin Time (PTT)
Normal range: 25-35 seconds
