Normo/Normo, Macro, & hemolytic Flashcards
What are the 4 causes of deficient erythropoieisis?
Renal Disease (any kidney damage)
Hypothyroidism (endocrine failure)
Aplastic Anemia
Myelophithisc
ACD can present as normo/normo as well as Micro/hypo
Decreased O2 need–> decreased ??? –> Decreased Basal Metabolism–> Decreased ???
EPO
RBC production
List causes of chronic kidney disease
Diabetes mellitus
Chronic Hypertension
Glomerulus Nephritis
Polycystic Kidney Disease
Recurrent Kidney Infection
Kidney excretory failure means it does not perform what two functions?
EPO secretion
Urine production
What do these symptoms indicate?
Edema & fluid build up
hypertension
fatigue
decrease urine output
increase in urination frequency
muscle cramping
Renal insufficiency
What will a CBC show of someone with kidney damage/renal insufficency?
Anemia
Normo/Normo
PBS= Echinocytes
What are the expected UA results of someone with renal damage?
Proteinuria
What additional tests can you run for someone that has expected kidney damage?
Kidney Function Test
Refer to Nephrologist for Renal Imaging
How can hypothyroidism cause a Normo/Normo anemia?
Decreased T4–> Decreased T3= decreased metabolism–> decreased O2 requirement–> decreased EPO output–> decreased RBC production
How can hypothyroidism cause a Hypo/Micro anemia?
Hypothyroid causes heavy menses–> chronic blood loss–> decreased iron ferritin–> decreased Iron serum–> IDA
How can hypothyroidism cause a Macrocytic anemia?
Decreased metabolism due to low T4 & T3–> decreased function of parietal cells–> decreased I.F. & decreased stomach acid–> decreased absorption of B12–> leads to decreased B12 deficiency= Macro.
What are the symptoms of Hypothyroidism? (7)
Fatigue
Brain fog
Increased sensitivity to cold
Constipation
Weight gain
Weakness
Thinning of out 1/3 of eyebrow
Since hypothyroidism can result in 3 different anemias what additional tests can be performed to diagnose it?
Thyroid Panel (determine function)
Iron panel
Serum B12 (can pair with a RBC folate test as well)
Patient with confirmed hypothyroidism has a macrocytic anemia from a B12 deficency. Best way to treat the patient?
Hormonal therapy. Correct the primary disease to treat the secondary disease as well.
What is the term for all of the tissue cells in the bone marrow has decreased production?
Panhypoplasia
(pancytopenia & hypocellular bone marrow)
What are the etiological causes of Aplastic Anemia?
Idiopathic
Drugs
Viral (immunocompromised)
Toxic exposure- glues, pesticides
Immune disorders
Congenital- Fanconi Anemia
Radiation treatment
What is the congenital cause of aplastic anemia called?
Fanconi Anemia- congenital failure of marrow
Which anemia has an increased susceptibilty to infections?
Aplastic anemia (decreased WBCs)
Aplastic anemia has an issue with bleeding tendencies due to?
Decreased platelets
What are the CBC findings of aplastic anemia?
Normo/Normo Anemia
Leukopenia of less than 1500 WBC
Neutropenia (all WBCs down)
Low reticulocyte count
Hypocellularity on bone marrow biopsy
Treatment for aplastic anemia?
Bone Marrow Transplant
(often refractory)
What are the 4 etiological causes of myelophthisic anemia?
Carcinoma metastasizing to bone marrow from primary tumor
Myelofibrosis
Myeloproliferative conditions
Osteopetrosis
What is myelofibrosis?
Polycythemia Vera elevating all cell lineages but leads to bone marrow replacement by scar tissue
What are 4 examples of myeloproliferative conditions?
Multiple myeloma, Leukemias, Lymphoma, Hodgkin’s