Normal and Abnormal Reproductive Development

Question 1

SRY gene function

Answer 1

secretes testes-determining factor

forms seminiferous tubules

Question 2

Production of ovaries requires what

Answer 2

two complete X chromosomes

Question 3

(47,XXY)

Answer 3

Kleinfelter syndrome

Question 4

Kleinfelter characteristics

Answer 4

infertility
gynecomastia
impaired sexual function

Question 5

Turner’s is due to loss of which chromosome

Answer 5

paternal chromosome

Question 6

True hermaphrodites are what genotype

Answer 6

XX

have one ovary and one testes

Question 7

Leydig cells

when are they functional

Answer 7

during fetal development
involute after birth
reappear after puberty

Question 8

Sertoli cells
function in development of male

Answer 8

secrete anti-Müllerian hormone

inhibits female duct system development

Question 9

Oocytes in prophase I until

Answer 9

shortly before ovulation

Question 10

Oocytes in metaphase II until

Answer 10

fertilization

causes release of 2nd polar body

Question 11

Paramesonephric duct in males

remnant becomes

Answer 11

prostatic utricle and appendix of testes

Question 12

Ureteric buds originate from

Answer 12

mesonephric ducts

Question 13

Paramesonephric ducts fuse to form what

in females

Answer 13

urogenital primordium

Question 14

Origin of upper 1/3 of vagina

and innervation

Answer 14

paramesonephric ducts

visceral sensory innervation

Question 15

Origin of lower 2/3 of vagina

and innervation

Answer 15

urogenital sinus

somatic sensory innervation

Question 16

Mesonephric duct remnant in women

Answer 16

Gartner’s duct or cyst

located outside uterus, may cause pain during intercourse

Question 17

Müllerian duct agenesis

Answer 17

results in absence of uterus and upper vagina

Question 18

Common malformation in uterus

Answer 18

septum in middle

can be removed

Question 19

Ectopic testes

refers to

Answer 19

displacement of testes

not in cryptorchism distribution

Question 20

Ventral fusion site of lateral penile folds

Answer 20

penile raphae

Question 21

Urogenital folds become what

in female

Answer 21

labia minora

Question 22

Labialscrotal swellings become what

in female

Answer 22

labia majora

Question 23

How does testosterone insensitivity cause female characteristics

Answer 23

lots of estrogen because of testosterone conversion

because of loss of negative feedback