Breast Cancer Cases

Question 1

Aromatase inhibitors only to be used in

Answer 1

post-menopausal women
because they work in non-ovarian tissue (adipose) to decrease androgen –> estrogen conversion
*may induce menopause if you want to do that

Question 2

Oncotype testing

Answer 2

21 RNA gene expression patterns

gives recurrence score number

Question 3

Tx of breast cancer if has low recurrence score

Answer 3

only tamoxifen ± surgery

chemo riskier than it’s worth

Question 4

Her2 typing

how does it contribute to risk

Answer 4

Her2+

automatically high risk

Question 5

High risk of recurrence is what %?

How does chemo reduce that risk?

Answer 5

25% risk of recurrence
chemo reduces that by 25%
ie 20% risk overall now

Question 6

What type of carcinoma is often not seen on mammogram

Answer 6

lobular carcinoma

Question 7

Lobular carcinoma

often located where

Answer 7

central part of breast

that means mastectomy is required, not lumpectomy

Question 8

DCIS is what stage ductal carcinoma

Answer 8

stage 0

Question 9

Tx of breast cancer in men

Answer 9

same as in women

Question 10

Which BRCA puts men at risk of breast cancer

Answer 10

BRCA2

Question 11

Not all cancers in the breast are breast cancers

Answer 11

others exist, his example was extranodal marginal zone lymphoma