Nonsteroidal Antiasthma Agents

Question 1

3 Types of Nonsteroidal Antiasthma Agents

Answer 1

• Cromolyn-like drugs (mast cell stabilizers)
• Antileukotrienes
• Monoclonal antibodies

Question 2

Mast Cell Mediators

Answer 2

• Histamine, Heparin, & Leukotrienes
• Mast cell mediator release is calcium-dependent and causes degranulation of mast cells, which causes bronchospasm, mucus production, and airway edema

Question 3

Goal of all Asthma/Allergy Medication

Answer 3

To stop or limit mast cell degranulation (decrease calcium)

Question 4

2 Mast Cell Stabilizers

Answer 4

cromolyn sodium and nedocromil sodium → directly prevent mast cell degranulation

Question 5

Leukotrienes

Answer 5

Are chemical mediators (leukocytes) that are potent bronchoconstrictors and stimulate other cells to cause inflammatory responses.

Question 6

Antileukotrienes

Answer 6

Attach to and block the receptor for Leukotrienes

Question 7

3 Types of Antileukotrienes

Answer 7

• Zileuton (Zyflo)
• Zafirlukast (Accolate)
• Montelukast (Singulair) - especially good for exercise- induced asthma

Question 8

Monoclonal Antibodies

Answer 8

Omalizumab (Xolair)