Nonsteroidal Anti- inflammatory Drugs (NSAIDs)

Question 1

Nonsteroidal Anti-
inflammatory Drugs (NSAIDs) Drug Names

Answer 1

Propionic Acids
Ibuprofen
Naproxen

Acetic Acids
Indomethacin
Ketolorac

Osicam derivatives
Meloxicam

Cyclooxygenase-2
Inhibitors
Celecoxib

Question 2

Nonsteroidal Anti- 
inflammatory Drugs (NSAIDs) Therapeutic Actions

Answer 2

• Provide strong anti-inflammatory and analgesic effects
• Sold over the counter, which may lead to abuse
• Antiinflammatory, analgesic, and antipyretic effects

Question 3

Nonsteroidal Anti-
inflammatory Drugs (NSAIDs) Indications

Answer 3

• Block two enzymes, known as COX-1 and COX-2

Question 4

Nonsteroidal Anti-
inflammatory Drugs (NSAIDs) Contraindications and Cautions

Answer 4

Contraindications:
• Allergy to any NSAID or salicylate, and celecoxib is also contraindicated in the presence of allergy to sulfonamides
• CV dysfunction or hypertension, peptic ulcer, GI bleeding
• Pregnancy, lactation
Cautions:
• renal and hepatic dysfunction

Question 5

Nonsteroidal Anti-
inflammatory Drugs (NSAIDs) DDI

Answer 5

DDI:
Decreased diuretic effect when these drugs are taken with loop diuretics; there is a potential for decreased antihypertensive effect of beta-blockers if these drugs are combined; and there have been reports of lithium toxicity, especially when combined with ibuprofen

Question 6

Nonsteroidal Anti-
inflammatory Drugs (NSAIDs) Adverse Effects

Answer 6

• Nausea
• Dyspepsia
• GI pain
• Constipation, diarrhea, or flatulence caused by direct GI effects of the drug.
• GI bleed
• Dizziness
• Somnolence
• Platelet inhibition
• Hypertension
• Bone marrow depression

Question 7

Nonsteroidal Anti-
inflammatory Drugs (NSAIDs):
Assessment

Answer 7

Assess:
Hx: allergies to any salicylates, NSAIs or tartrazine, pregnancy and lactation, hepatic or renal disease; CV dysfunction, hypertension; GI bleeding or peptic ulcer
Physical: vital signs, skin, temp, orientation and reflexes, perfusion, respirations and adventitious sounds; liver evaluation, BS (baseline)
Labs: kidney, liver function

Question 8

Nonsteroidal Anti-
inflammatory Drugs (NSAIDs) Diagnosis

Answer 8

Dx:

• Acute pain: to CNS, GI effects
• Ineffective breathing pattern is toxic effects occur
• Disturbed sensory perception is toxic effects occur
• Deficient knowledge: drug therapy

Question 9

Nonsteroidal Anti-
inflammatory Drugs (NSAIDs):
Implementation

Answer 9

Implementation:
• Administer with food if G.I. upset is severe; provide small, frequent meals
• Check all drugs being taken for possible salicylate ingredients
• Monitor for severe reaction
• Ensure the patient is well hydrated during therapy
• Provide thorough patient teaching

Question 10

Nonsteroidal Anti-
inflammatory Drugs (NSAIDs):
Evaluation

Answer 10

Eval:
Response to the drug 
Adverse effects 
Effectiveness of comfort measures Compliance with the regimen
Effectiveness of the teaching plan