Nonrespiratory sleep disorders Flashcards
1
Q
What is the pathogenesis of narcolepsy
A
1) Gliosis of the lateral hypothalamus resulting in hypocretin/orexin deficiency
2) Susceptibility in those with HLA DQB1*0602
2
Q
Diagnosis of narcolepsy by MSLT
A
Mean sleep latency onset time < 8 min
>/= 2 SOREMPs
3
Q
Treatment regimen for narcolepsy
A
1) Scheduled naps
2) Stimulants - modafinil and armodafinil
3) Amphetamines are second line
4) SSRIs for mild cataplexy
5) Xyrem for difficult to manage cataplexy
4
Q
Diagnose idiopathic hypersomonia
A
Sleep latency onset < 8 min
No more than one SOREMP
5
Q
Treatment of IH
A
Stimulants like modafinil or armodafinil
