Noninflammatory Joint Pathology Flashcards
What is joint degeneration?
A disease in which the function or structure of the affected tissues or organs changes for worse over time
Joint degeneration is driven by…
the mechanical wear of joints
Joint degeneration is characterized by…
progressive destruction of articular cartilage at synovial joints
Is joint degeneration inflammatory?
No
What is the most common joint problem in humans?
Joint degeneration
Primary joint degeneration is an ___-related pathology
age-related
What mutation is a genetic factor related to cartilage formation that may cause joint degeneration?
Mutations in type II collagen gene (COL2A1)
___% of 75-79 years of age are affected by joint degeneration
85%
Before age 45, joint degeneration is more common in ___
men
After age 55, joint degeneration is more common in ___
women
What is secondary joint degeneration?
Due to an underlying cause
What are some etiologic factors of joint degeneration?
- Increased unit load
- Disruption of water bonding (decreased resilience)
- Subchondral stiffening
- Biochemical changes
Which biochemical changes are etiologic factors for joint degeneration?
- Decreased proteoglycans
- Glycosaminoglycan chain length reduced
- Increased fibrillin
- Increased water binding
- Collagenase present
