Nondisjunction, aneuplodies 6.2 Flashcards
Disjunction
Separation of chromosomes
Nondisjunction
When chromosomes fail to separate
What does aneuploidy occur through?
Nondisjunction
When can nondisjunction occur?
Mitosis, meiosis I or meiosis II, spermatogensis or oogenesis
Turner syndrome
X0
Klinefelter syndrome
XXY
Triple X syndrome
XXX
Tetrasomy X
XXXX
Pentasomy
XXXXX
Jacobs syndrome
XYY
Aneuploid
an abnromal number of one or more chromsomes
Polyploid
When there are >2 complete sets of chromosomes (not viable in humans)
Mosacisim
When different cells have different karyotypes
Gynandromorph
bilateral development can leave one side of the body to develop as male, and the other side as female
X inactivation
One X chromosome is randomly inactivated during embryonic development through chromatin condensing (lyonization), forming Barr bodies
How many bar bodies? XY
0
How many bar bodies? XX
1
How many bar bodies? XXX
2