Non Mendelian Inheritance 5.3 Flashcards
Complex (quantitative) traits
demonstrate continuous phenotypic variation
More of a distribution, not tall or short
Do not behave according to Mendelian genetic predictions
Complex traits are due to
environment, genetics, gene by enviroment interactions
The 6 (single loci) and 2 (multi loci) non-mentalian inheritance
Single loci:
Incomplete dominance
Codominance
Maternal effects and cytoplasmic inheritance
Sex-influenced and sex-limited traits
Lethal alleles
Conditional alleles
Multi loci:
additive traits
Epistasis
Incomplete dominance
When the phenotype of heterozygotes is intermediate between either homozygote
Incomplete dominance ratio
1:2:1
Codominance
When the phenotype of heterozygotes presents the phenotypes of both homozygotes
Codominance ratio
1:2:1
Recessive lethal alleles
Lethal alleles can lead to missing or reduced numbers of genotypes
Recessive lethal alleles ratio
2:1
Organelle inheritance
During mitosis and meiosis, different quantities of organelles are inherited
mtDNA/cpDNA will not be inherited according to mendelian ratio and is not predictable
Sex-limited and sex-influenced traits are influenced by genes on the autosomes or sex chromsome?
autosome
Sex limited traits
when the trait is only expressed in one sex
Sex influenced (or sex associated)
when the trait is mostly expressed in one sex
Conditional lethal alleles
When alleles are only lethal under certain environmental conditions
Favism
a condition caused by X-linked recessive mutations in the gene encoding glucose-6-phosphate dehydrogenase Xg6Xg6
Degree of dominance (h)
described the degree to the phenotype of the heterozygote resembles the phenotype of a homozygous parent
Range: 0 to 1
expressivity
people with same genotype present varying phenotypic range
penetrance
the proportion of individuals with a particular genotype that also express the associated trait
incomplete penetrance
when some individuals with a particular genotype express the trait, while others do not
Penetrance equation
Penetrance= (# of individuals with the trait/ total # of individuals that should have the trait) * 100