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5. Cc > Non Protein Nitrogen > Flashcards

Non Protein Nitrogen Flashcards

1
Q

originated in the early days of clinical
chemistry when analytic methodology required removal of protein from a
specimen before analysis.

A

Nonprotein nitrogen

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2
Q

Major excretory product of protein
metabolism

A

Urea

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3
Q

waste product product protein

A

Urea

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4
Q

principal of waste product muscle

A

Creatinine

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5
Q

enzymatic phosphate

A

Creatine

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6
Q

Importance detects renal function

A

Urea

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7
Q

It is also the first metabolite
to increase in kidney disease,

A

Blood urea nitrogen ( BUN)

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8
Q

It is used as a screening test for kidney
disease.

A

BLOOD UREA NITROGEN ( BUN)

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9
Q

is readily removed by dialysis.

A

Urea

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10
Q

Major organic solid in the urine

A

Blood urea nitrogen ( BUN)

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11
Q

CLINICAL APPLICATION BUN

A

 evaluate renal function,
 to assess hydration status,
 to determine nitrogen balance,
 to aid in the diagnosis of renal disease, and
 to verify adequacy of dialysis

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12
Q

Mixture of sulfuric acid and phosphoric acid

A

Kjeldahl process

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13
Q

Oldest method BUN

A

MICRO-KJELDAHL NESSLER

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14
Q

Major inorganic solid in the urine

A

Chloride

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15
Q

Urea measured wavelength at

A

340 nm

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16
Q

Urease Berthelot Method end color

A

indophenol blue

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17
Q

Urease nessler method chemical used

A

Urease

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18
Q

Enzymatic method complex enzymes

A

L glutamate dehydrogenase

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19
Q

Enzymatic method convert

A

NADH AND NAD

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20
Q

Urea convert carbon dioxide and ammonia

A

Urease berthelot method

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21
Q

Yellow diazine derivatives (yellow) called

A

Fearson reaction

22
Q

Urea is made to react with diacetyl
monoxime to produce a yellow diazine
derivative (Fearon’s reaction).

A

Diacetyl Monoxime Method (DAM)

23
Q

containing anticoagulants are
contraindicated in enzymatic methods.

A

Ammonium oxalate

24
Q

inhibits the action of
urease.

A

Sodium fluoride and citrate

25
Q

Upon prolonged standing, ammonia concentration
in the sample rises 2-3 times the original value
due to enzymatic deamination of labile amide like

A

glutamine

26
Q

NORMAL VALUE: BUN

A

6-20 mg/dl

27
Q

24hr urine: BUN

A

12-20 mg/dl

28
Q

Conversion factor of bun

A

0.357

29
Q

Urea nitrogen concentration can be converted to urea
concentration by multiplying by

A

2.14

30
Q

Urea nitrogen concentration expressed in milligrams per deciliter
may be converted to urea concentration in millimoles per liter by
multiplying by

A

0.167

31
Q

It is synthesized form three amino acids of creatinine

A

methionine, arginine and
lysine

32
Q

Fetal kidney maturity

A

Creatinine

33
Q

Urease came from

A

Jack bean

34
Q
  • production of constant
A

Creatinine

35
Q

Not easily removed by Dialysis

A

Creatinine

36
Q

The most commonly used assay for Renal Blood Flow

A

Creatinine

37
Q

GFR HIGH CREATININE IS

A

Low

38
Q

Available on Ektachem analyzer

A

Creatinase method

39
Q

Oxidation of indicator in creatinase

A

Hydrogen peroxide

40
Q

Creatinine is hydrolyzed to creatine by creatinine
aminohydrolase followed by a series of coupled enzyme
reactions in which creatine reacts with creatinine kinase,
pyruvate kinase, and lactate dehydrogenase, culminating in
the oxidation of the NADH.

A

Creatinine Aminohydrolase Method

41
Q

PRINCIPLE OF CREATININE DETERMINATION:

A

Jaffe reaction

42
Q

Jaffe reagent

A

Picric acid + sodium hydroxide = alkaline solution

43
Q

Jaffe end color

A

Red orange

44
Q

Absorbent of creatinine

A

Lloyds reagent
Fuller earth reagent

45
Q

Lloyd’s Reagent is

A

sodium aluminum silicate

46
Q

Fuller Earth’s Reagent is

A

aluminum magnesium silicate

47
Q

Conversion factor of creatinine

A

88.4

48
Q

Colorimetric of Simple and Non specific

A

Endpoint

49
Q

Colorimetric of Rapid and increased specificity

A

Kinetic

50
Q

CLINICAL SIGNIFICANCE: creatinine

A

 Muscular dystrophies
 Familial periodic paralysis
 Myasthenia gravis
 Dermatomyositis

51
Q

defined as the increased in urea and
creatinine (azotemia) with accompanying clinical
signs and symptoms of renal failure

A

Uremia

52
Q

defined as the increased in urea and
creatinine (azotemia) with accompanying clinical
signs and symptoms of renal failure

A

Uremia

5. Cc (3 decks)

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