Non-Oncogene Addiction

Question 1

Give examples of non-oncogene addictions in cancer cells

Answer 1

Dependence on heterotypic signalling
Dependence on prosurvival pathways
Dependence on angiogenesis
Glucose dependence
Dependence on stress supports; oxidative stress, dna damage stress, mitotic stress, proteotoxic stress

Question 2

What is velcade/bortezomib?

Answer 2

Proteosome blocker

Main target is chymotrypsin-like activity at the beta5 subunit (PSMB5)

Question 3

How does velcade/bortezumab work?

Answer 3

Prevents proteosome activity and so destruction of dysfunctional proteins and so disrupts the protein homeostasis of the cell, submitting it to proteosome stress.

Question 4

Which cancers does velcade/bortezumab work in and why?

Answer 4

Multiple myeloma
Mantle cell lymphoma.
Two theories;