Non-Narcotic Analgesics Flashcards
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- Signs of gastropathy develop in the patient with
rheumatoid arthritis who was treated with indometacin. With what activity of the drug can this complication be connected?
A Anticyclooxygenase
B Antiserotonin
C Antihistamine
D Antikinine
Anticyclooxygenase
- A female patient consulted a doctor about ^pain and limited movements in the knee joints^. Which of the following nonsteroid anti-inflammatory drugs should be administered taking into consideration that the patient has a history of chronic gastroduodenitis?
A Celecoxib B Diclofenac sodium C Promedol D Acetylsalicilic acid E Butadiounum
Celecoxib
- Reduce of influence on which molecular substrate leads to ^decrease of ulcerogenic^ action of nonsteroid anti-inflammatory agents?
A. Cyclooxvgenase-1 B. Kallikrein C. Lysosomal enzymes D. Cyclooxvgenase-2 E. Adenylate cyclase
Cyclooxygenase-1
- The 63 years old patient with ^arthritis^ on a background of treatment by aspirin (acetyisalicylic acid) has complained of nausea, gravity in epigastrium. The doctor has abolished aspirin and has administered the antiinflammatory agent from the group of selective COX-2 inhibitors. Indicate this drug.
A. Meloxicam' B. Voltarenum (diclofenac-sodium) С. Indomethacinum D. Naproxenum E. Butadionum (phenylbutazone)
Meloxicam
- The doctor has administered an ointment containing anti-infiammatory agent from the group of ^pyrazolone derivatives^ to the patient with arthritis of maxillofacial joint. What agent is contained in the ointment?
A. Butadionum (phenylbutazone) B. Mefetmmic acid С. Ibufrofenum D. Indomethacinum E. Diclofenac-sodium
Butadionum (phenylbutazone)
- Indicate the drug from the group of nonsteroid anti-inflammatory agents which exerts the most prominent anti-inflammatory action in collagenoses?
A. Iindomethacinum B. Aspirin (acetylsalicylic acid) С. Ibuprofenum D. Butadionum (phenylbutazone) E. Ortophenum (diclofenac-sodium)
Iindomethacinum
- The 55 years old patient, developed gastric hemorrhage on the 7-th day of treatment with Indomethacinum. Indicate the pharmacological effect of the drug which explains this complication.
A. Diminution of formation of Prostaglandin El
B. Diminution of formation of letuotrien
С Diminution of formation of Prostaglandin E2
D. Diminution of formation of cyclic endoperoxides
E. Diminution of formation of thromboxane
Diminution of formation of Prostaglandin El
- Nonsteroid anti-inflammatory agents are effective at treatment of rheumatic disease owing to ability to oppress:
A. Cyclooxygenase-2 B. Phospholipase-A2 C. Cyclooxygenase-1 D. Adenylatcyclase E. Peroxidase
Cyclooxygenase-2
- It is known, that nonsteroid anti-inflammatory drugs are widely used for treatment of rheumatic disease. They influence what of inflammatory process?
A. Exudative B. Phase of alteration C. Phase of a proliferation D. All phases of an inflammation E. Autoimmune
Exudative
- The patient was treated by nonopioid analgesic due to backache. In several days he started to complain of dyspeptic disorders and stomachache (in anamnesis the patient had hyperacidic gastritis). Indicate the reason of the arisen complication.
A. Inhibition of synthesis of prostaglandins in gastric mucosa
B. Stimulation of parasympathetic innervation by the stomach
C. Inhibiton of mucous production by the gastric mucosa
D. Inhibition of regeneratory activity of the gastric
mucosa
E. Inhibition of organotrophic sympathetic influences
upon the stomach
Inhibition of synthesis of prostaglandins in gastric mucosa
- Following signs have developed at the patient after several days of treatment by the drug with analgesic, antipyretic and anti-inflammatory activity: headache, giddiness, sonitus, nausea, pain in epigastric area. Specify the drug which could produce similar clinical pattern.
A. Aspirin B. Naphthyzinum (naphazoline) C. Bromhexinum D. Midantanum (amantadine) E. Vitamin С
Aspirin
Specify the most typical side-effects of butadionum,
A. Dispeptis disorders B. Suppression of the CNS C. Hypothermia D. Arterial hypotension E. Allergic reactions
Dispeptis disorders
- The patient with systemic lupus erythematosus was treated for a long time by non-steroid anti-inflammatory agents. However, recently his condition has considerably worsened. Which drug is necessary to administer to the patient?
A. Prednisolone B. Analginum (Metamizole) C. Dimedrolum (Diphenhydramine) D. Thymalinum E. Polyvitamins
Prednisolone
- Non-steroidal anti-inflammatory agent was
administered to a patient with rheumatic polyarthritis. In several weeks weakness and indisposition were arisen. The clinical examination of the patient revealed ^necrotic quinsy^ and ^leucopenia^. What drug could cause this complication?
A. Analginum (Metamizole) B. Paracetamolum C. Nitrazepam D. Omnopon E. Morphine
Analginum (Metamizole)
- Non-steroidal anti-inflammatory agents are used for the treatment of following pains, except:
A. Fractures of bones B. Headache C. Arthritis D. Neuritis E. Toothache
Fractures of bones