Non-melanoma skin cancer Flashcards

1
Q

most common skin cancer

A

basal cell carcinoma (BCC)

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2
Q

where do BCCs arise from

A

keratinocytes in basal layer of epidermis

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3
Q

prognosis of basal cell carcinoma

A

very good prognosis - locally invasive but rarely metastasise

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4
Q

types of BCC

A

nodular

superficial spreading

infiltrative/morphoeic

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5
Q

most common type of BCC

A

nodular

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6
Q

presentation nodular BCC

A

slow growing shiny, pearly nodule with rolled edge, central ulceration, telangiectasia sun exposed sites

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7
Q

where on body are superficial spreading BCCs often found

A

trunk

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8
Q

gold standard treatment for BCC

A

excision biopsy with 4mm margins

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9
Q

what surgical option can be used for difficult sites when tissue preservation is important e.g. eyelid

A

moh’s surgery

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10
Q

what other treatment options may be appropriate for small BCC’s

A

curettage (<1cm)

cryotherapy

topical therapy - 5 fluorouracil / imiquimod

– incisional biopsy still needed to confirm diagnosis

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11
Q

pre-malignant lesions for squamous cell carcinoma

A

actinic keratosis

bowens disease

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12
Q

appearance of actinic keratosis

A

thick, rough, scaly, red/yellow lesions on sun exposed sites

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13
Q

what things may raise suspicions of malignancy in actinic keratosis

A

>1cm

growing

thick

bleeding

painful

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14
Q

treatment of actinic keratosis

1-2 lesions

>2 lesions

A

1-2: cryotherapy

>2: 5 fluorouracil cream (efudix)

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15
Q

what is bowens disease

A

intra-epidermal squamous cell carcinoma

  • SCC in situ
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16
Q

presentation of bowens disease

A

well definied, red, scaly plaque

usually on leg / other sun exposed sites

17
Q

treatment of bowens disease

A

5-fluorouracil

cryotherapy

18
Q

what cancer is more common in immunosuppressed / transplant patients

A

SCC

19
Q

Presentation of SCC

A

rapily growing painful, ulcerated irregular lesion with hard raised edge

found on sun exposed sites

20
Q

what are SCC’s on the lip linked to

A

smoking

21
Q

Treatment of SCC

A

surgical excision 4mm margin

22
Q

what treatments can be used in superficial SCCs

A

topical 5-fluorouracil / imiquimod

23
Q

what antibiotic can be used in mild actinic keratosis treatment

A

topical diclofenac

24
Q

do invasive BCCs respond well to chemo or radiotherapy?

A

radiotherapy

25
Q

describe the dysplastic change in

  1. actinic keratosis
  2. bowens disease
  3. SCC
A
  1. AK = partial thickness dysplasia
  2. bowens = complete thickness dysplasia
  3. SCC = complete thickness dysplasia + invasive
26
Q

rapidly growing lesion over 6-8 weeks then disappears

suggestive of?

A

keratoacanthoma

  • dont metastasise
  • excised to check histology for SCC
27
Q

genetic mutation in 90% of BCCs

A

inactivating mutation in PTCH gene

28
Q

presentation of merkel cell tumour

A

raised, red rapidly growing lesion

  • poor prognosis
29
Q

what is actinic cheilitis

A

actinic keratosis on the lips

30
Q

what can cutaneous horns be a feature of

A

SCC

seborrhoeic keratosis

HPV