Non-Insulin Treatments for Diabetes Flashcards
1
Q
What is the A1C range that warrants the use of 2 drugs for the inital treatment?
A
8.5 - 10
2
Q
List the three SGLT2i with cardiorenal benefits
A
- Invokana
- Farxiga
- Jardiance
3
Q
List the three GLP-1a with cardiorenal benefits
A
- Trulicity
- Victoza
- Ozempic
4
Q
When to avoid
Metformin
A
- Lactic acidosis
- Renal insufficiency (eGFR < 30)
5
Q
When to avoid
Sulfonylureas
A
- Sulfa allergy
- If pt is on a meglitinide
- Hypoglycemia
- Weight gain/obesity
- Renal insufficiency (glyburide)
Meglitinides: repaglinide, nateglinide
6
Q
When to avoid
Meglitinides
A
- If pt is on a sulfonylurea
- Hypoglycemia
- Weight gain/obesity
7
Q
When to avoid
TZDs
A
- Heart failure
- Osteopenia/osteoporosis
- Weight gain/obesity
8
Q
When to avoid
DDP-4i
A
- If pt is on a GLP-1 or a GLP-1/GIP
- Pancreatitis
- Heart failure (saxagliptin, alogliptin)
9
Q
When to avoid
GLP-1 agonists and GLP-1/GIP agonists
A
- If pt is on a DPP-4i
- Cancer (thyroid, including medullary thyroid carcinoma)
- Gastroparesis and GI disorders
- Pancreatitis
- Renal insufficiency (Exenatide)
10
Q
When to avoid
Pramlintide
A
- Gastroparesis and GI disorders
- Hypoglycemia
11
Q
When to avoid
SGLT2i
A
- Genital infection/UTI
- Hypotension/dehydration
- Ketoacidosis
- Peripheral neuropathy, PAD, foot ulcers (Invokana)
- Osteopenia/osteoporosis (Invokana)
