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Therapeutics 2 Drugs - Fall 2018 > Non-insulin medications > Flashcards

Non-insulin medications Flashcards

Classification, dosing, AE and CI

1
Q

Name the DPP-IV

A 
"gliptins" 
Sita
Saxa
Lina
Alo
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2
Q

Dosing for Sitagliptin

A

CrCl >50 100mgd
CrCl 30-50 50mgd
CrCl <30 25mgd

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3
Q

Dosing for Saxagliptin

A

CrCl >50 2.5-5mgd

CrCl <50 2.5mgd

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4
Q

Dosing for Linagliptin

A

5mgd

NO RENAL ADJUSTMENT

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5
Q

Dosing for Alogliptin

A

CrCL >60 25mgd
CrCL 30-60 12.5mgd
CrCL <30 6.25mgd

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6
Q

Dosing for Metformin

A

Initial: 500mg BID or 825mg d
Max 2g/d
CrCl >60 monitor SrCl annually
CrCl 45-60 Monitor SrCl q3-6m
CrCl 30-45 reduced dose by 50% do not start therapy
CrCl <30 Do not start therapy. D/C if already on therapy

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7
Q

Name the SGLT-2 inhibitors

A 
"flozins" 
Cana
Dapa
Empagla
Ertugl
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8
Q

Dosing for Canagliflozin

A

CrCl >60 100mgd- 300mgd
CrCl 45-60 100mgd MAX
CrCl <45 DO NOT USE

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9
Q

Dosing for Dapagliflozin

A

CrCl >60 5mgd

CrCl <60 DO NOT USE

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10
Q

Dosing for Empagliflozin

A

CrCl >45 10mgd- 25mgd

CrCl <45 DO NOT USe

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11
Q

Dosing for Ertugliflozin

A

CrCl > 60 5mg-15mgd

CrCl < 60 DO NOT USE

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12
Q

Dosing for Sulfonylureas

A

“ides”
Glipi
Glybur
Glime

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13
Q

Dosing for Glimepride

A

1-2 mgd

Max 8mg

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14
Q

Dosing for Glyburide

A

1.25- 5mgd
Max 20mg

Micronized: 1.25- 5mgd
Max 12mg

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15
Q

Dosing for Glipizide

A

2.5-5mgd
Max 40mg

XL: 2.5-5mgd
Max 20mg

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16
Q

Name the GLP-1 Agonists

A 
"tides" 
Sema
Lira
Dula
Lixi
Exena
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17
Q

Dosing for Semaglutide

A
  1. 25mg Sq x 4 weeks once weekly

0. 5mg Sq or 1 mg once weekly

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18
Q

Dosing for Exenatide

A

Take 60min before meals!

Short-acting:
5mcg SQ BID x 1 month
10mcg SQ BID

Long-acting:
2mg SQ once weekly

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19
Q

Dosing for Dulaglutide

A

0.75-1.5mg SQ weekly

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20
Q

Dosing for Liraglutide

A
  1. 6mg SQ once a day x 7 days

1. 8mg SQ once a day

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21
Q

Dosing for Lixisenatide

A

10mcg SQ x 2 weeks daily

20mcg SQ

22
Q

Name the Meglitinides

A

“glinides”
Repa
Nate

23
Q

Dosing for Repaglinide

A

A1C > 8% 1-2mg with food
A1C < 8% 0.5mg with food
Max 6mgd

24
Q

Dosing for Nateglinide

A

A1C > 8% 120mg with food
A1C < 8% 60mg with food
Max 360mgd

25
Name the Thiazolidinediones
"zones" Pio Rosi
26
Dosing for pioglitazone
initial: 15-30mgd Max: 30-45mgd
27
Dosing for Rosiglitazone
initial: 4mgd Max: 8mgd
28
Name the Amylin mimetic
Pramlintide
29
Dosing for Pramlintide
Take before meal! T1DM 15mcg--> titrate by 15mcg to 30-60mcg T1DM 60mcg--> titrate to 120mcg
30
AE of metformin
GI- N/V/D Vit B12 deficiency LA
31
AE in GLP-1
Dose-dependent N/V Hypoglycemia Pancreatitis Thyroid Cancer risk
32
AE in DPP-IV
Pancreatitis Nasopharyngitis Headache Upper respiratory infections
33
AE in SGLT-2
``` UTI Yeast infections Increased urination hypoglycemia hyperkalemia increase in cholesterol ```
34
AE in Sulfonylureas
``` Hypoglycemia Weight gain GI upset Allergic skin reaction Hematologic ```
35
AE in Thiazolidinediones
Hepatotoxicity Exacerbations of HF Macular Edema Increased fracture risk
36
AE in Meglitinides
Hypoglycemia | Weight gain
37
AE in Alpha-glucosidase inhibitors
GI upset Rashes Increased liver function tests
38
AE in Amylin mimetics
Severe hypoglycemia when used with insulin N/V Anorexia
39
AE in Insulin
``` Weight gain Hypoglycemia Lipodystrophy Lipoatrophy Insulin resistance ```
40
CI in HF (III-IV)
Metformin DPP-IV Caution with TZDs
41
CI in Kidney Disease
``` Metformin CrCl < 30 Canagliflozin CrCl < 45 Dapaflozin CrCl < 60 Empagliflozin CrCl <45 Ertugliflozin CrCl <60 Caution in sulfonylureas ```
42
CI in fracture risk
Canagliflozin | TZDs
43
CI in pancreatitis
DPP-IV | GLP-1
44
CI in liver disease
TZDs | Caution with: meglitinides and Sulfonylureas
45
CI in joint pain
DPP-IV
46
CI in Thyroid Cancer hx or FH
GLP-1
47
CI in GI disorders
Alpha-glucosidase
48
CI in alcoholism
Caution with metformin and sulfonylureas
49
CI in Age
Caution with: Metformin, sulfonylureas, and meglitinides
50
CI in DKA
Metformin Meglitinides Caution with SGLT-2

Therapeutics 2 Drugs - Fall 2018 (5 decks)

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