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Therapeutics 2 Drugs - Fall 2018 > Insulins > Flashcards

Insulins Flashcards

1
Q

Ultra Rapid Onset Insulin(s)

A

Lispro (Humalog)
Aspart (Novolog)
Glulisine (Aprida)

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2
Q

Mechanism of action of Insulin Lispro (Humalog)

A

P28 and K29 switch locations preventing dimerization

Decreases glucose production and increases glucose utilization

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3
Q

Mechanism of action of Insulin Aspart (Novolog)

A

P28 is changes to D28, prevents dimerization

Decreases glucose production and increases glucose utilization

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4
Q

Mechanism of action of Insulin Glulisine (Aprida)

A

Change of N3 to K3 and L29 to E29, prevents dimerization

Decreases glucose production and increases glucose utilization

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5
Q

When is the time of onset in ultra rapid insulins?

A

15-30min

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6
Q

What is the duration of action of ultra rapid insulins?

A

3-5 hours

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7
Q

When is the peak action of ultra rapid insulins reached?

A

1-2 hours

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8
Q

Dosage forms of Insulin Lispro (Humalog)

A

Pen, vial, cartridge

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9
Q

Dosage forms of insulin Glulisine (Aprida)

A

Cartridge and pen system

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10
Q

Dosage forms of insulin Aspart (Novolog)

A

Pen, vial, cartridge

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11
Q

Short Acting Insulin(s)

A

Regular Insulin (Humulin R)

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12
Q

Dosage forms of Regular Insulin (Humulin R)

A

Pen, vial, cartridge

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13
Q

When is the onset of Insulin Regular (Humulin R)?

A

30-60 min

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14
Q

What is the duration of action of insulin Regular (Humulin R) ?

A

4-6hrs

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15
Q

When is the peak concentration of insulin Regular (Humulin R) reached?

A

2-3 hrs

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16
Q

What other insulin(s) is Insulin Regular (Humulin R) compatible with?

A

NPH

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17
Q

What other insulin(s) is Insulin Glulisine (Aprida) compatible with?

A

NPH

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18
Q

What other insulin(s) is Insulin Lispro (Humolog) compatible with?

A

NPH

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19
Q

What other insulin(s) is Insulin Aspart (Novolog) compatible with?

A

NPH

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20
Q

Intermediate acting insulin(s)

A

NPH

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21
Q

Doage forms of NPH

A

Pen, vial

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22
Q

When is the peak concentration of NPH reached?

A

4-8hrs

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23
Q

When is the onset of NPH?

A

2-4hrs

24
Q

What is the duration of action of NPH?

A

8-12 hrs

25
Q

What other insulin(s) is NPH compatible with?

A

Regular
Lispro
Aspart
Glulisine

26
Q

Long acting insulin(s)

A

Glargine (Lantus)

Detemir (Levemir)

27
Q

Dosage forms of Insulin Glargine

A

Pen, vial, cartridge

28
Q

Doage forms of insulin Detemir (Levemir)

A

Pen, vial, cartridge

29
Q

When is the onset of insulin Glargine (Lantus)?

A

4-5 hrs

30
Q

When is the onset of insulin Detemir (Levemir)?

A

2 hrs

31
Q

When is the peak concentration of insulin Glargine (Lantus) reached?

A

N/A

32
Q

When is the peak concentration of insulin Detemir (Levemir) reached?

A

N/A

33
Q

What is the duration of action of insulin Glargine (Lantus)?

A

22-24 hrs

34
Q

What is the duration of action of insulin Detemir (Levemir)?

A

14-24hrs

some pts are dosed BID due to the large range of DOA

35
Q

What other insulin(s) is insulin Detemir (Levemir) compatible with?

A

None

36
Q

What other insulin(s) is insulin Glargine (Lantus) compatible with?

A

None

37
Q

Ultra long acting insulin(s)

A

Degludec (Tresiba)

38
Q

Dosage forms for Degludec (Tresiba)

A

Pen

39
Q

When is the onset of insulin Degludec (Tresiba)?

A

1-2hrs

40
Q

When is the peak concentration of Degludec (Tresiba)?

A

N/A

41
Q

What is the duration of action for Degludec (Tresiba)?

A

Over 24hrs (~40hrs)

42
Q

What other insulin(s) is insulin Degludec (Tresiba) compatible with?

A

None

43
Q

Name the concentrated insulins (5)

A

Humulin-R U500

Degludec U200 (Tresiba)

Glargine U300
(Toujeo)
Glargine U 300 (Toujeo Max)

Lispro U200
(Humalog Kwikpen)

44
Q

What is the maximum single dose delivery of Humulin R U500?

A

300units

45
Q

What is the maximum single dose delivery of Degludec U200?

A

160units

46
Q

What is the maximum single dose delivery of Toujeo (Glargine U300)

A

80units

47
Q

What is the maximum single dose delivery of Toujeo Max (Glargine U300)

A

160units

48
Q

What is the maximum single dose delivery of Humalog Kwikpen (Lispro U200)

A

60units

49
Q

What is the duration of action of Humulin R U500?

A

6-10hrs

50
Q

What is the duration of action of Degludec U200 (Tresiba)?

A

42hrs

51
Q

What is the duration of action of Glargine U300 (Toujeo and Toujeo Max)?

A

> 30hrs

52
Q

What is the duration of action of Lispro U200 (Humalog Kwikpen)?

A

3-4hrs

53
Q

How many units are in the Humulin R U500 pen?

A

1500units/3mL pen

54
Q

How many units are in th Degludec U200 (Tresiba) pen?

A

600units/3mL pen

55
Q

How many units are in the Glargine U300 (Toujeo) pen?

A

450units/1.5mL pen

56
Q

How many units are in the Glargine U300 (Toujeo Max) pen?

A

900units/3mL pen

57
Q

How many units are in the Lispro U200 Humalog Kwikpen?

A

600units/3mL pen

Therapeutics 2 Drugs - Fall 2018 (5 decks)

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